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Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
The field of nasal drug delivery gained enormously on interest over the past decade. Performing nasal in vivo studies is expensive and...
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Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway
Spinal cord injury (SCI) can prompt an immediate disruption to the blood–spinal cord barrier (BSCB). Restoring the integrity of this barrier is vital...
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Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling
The dense cancer microenvironment is a significant barrier that limits the penetration of anticancer agents, thereby restraining the efficacy of...
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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals
PurposeThere is growing interest in seeking pharmacological activation of neurolysin (Nln) for stroke treatment. Discovery of central nervous system...
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Activation of NMDA receptors in brain endothelial cells increases transcellular permeability
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose. In...
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An In Vitro Bilayer Model of Human Primary Retinal Pigment Epithelial and Choroid Endothelial Cells for Permeability Studies
The blood-retinal barrier (BRB) present in the posterior chamber of the eye plays a major role in maintaining the proper function and integrity of...
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Choroid plexus enlargement in amyotrophic lateral sclerosis patients and its correlation with clinical disability and blood-CSF barrier permeability
BackgroundUsing in vivo neuroimaging techniques, growing evidence has demonstrated that the choroid plexus (CP) volume is enlarged in patients with...
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Brain Endothelial Cells Utilize Glycolysis for the Maintenance of the Transcellular Permeability
Among the components of the blood–brain barrier (BBB), endothelial cells (ECs) play an important role in supplying limited materials, especially...
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Pivotal role of permeability-glycoprotein in absorption of praziquantel into Dicrocoelium dendriticum parasite
Dicrocoelium dendriticum affects the livers of ruminants and causes several deleterious effects on animal health status. The aim of this study was to...
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In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules
PurposeThis study investigates in silico the contribution of the hair follicle to the overall dermal permeability of small molecules, as published...
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Converting Tretinoin into Ionic Liquids for Improving Aqueous Solubility and Permeability across Skin
PurposeThe aim of this study is to convert tretinoin (Tr), an active pharmaceutical ingredient (API), into ionic liquid for improving aqueous...
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Preparation of Conotoxin-Encapsulated Chitosan Nanoparticles and Evaluation of Their Skin Permeability
μ-Conotoxin CnIIIC (conotoxin, CTX)–loaded chitosan nanoparticles (CTX-NPs) were prepared using the ionic cross-linking method. The CTX-NPs were...
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Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following...
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Role of Tissue Hydraulic Permeability in Convection-Enhanced Delivery of Nanoparticle-Encapsulated Chemotherapy Drugs to Brain Tumour
PurposeTissue hydraulic permeability of brain tumours can vary considerably depending on the tissue microstructure, compositions in interstitium and...
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The effect of rugby training on indirect markers of gut permeability and gut damage in academy level rugby players
PurposeTo assess indirect markers of intestinal endothelial cell damage and permeability in academy rugby players in response to rugby training at...
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Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath
BackgroundAstrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and...
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Interleukin-6 Downregulates the Expression of Vascular Endothelial-Cadherin and Increases Permeability in Renal Glomerular Endothelial Cells via the Trans-Signaling Pathway
The pathogenesis of IgA nephropathy (IgAN) is still unknown, but reportedly, interleukin 6 (IL-6) is involved in this process. However, its role in...
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PTEN-induced kinase 1 deficiency alters albumin permeability and insulin signaling in podocytes
Alterations of insulin signaling in diabetes are associated with podocyte injury, proteinuria, and renal failure. Insulin stimulates glucose...
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Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis
Neurotropic viruses can infiltrate the CNS by crossing the blood–brain barrier (BBB) through various mechanisms including paracellular,...
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gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema
Angioedema is characterized by swelling of the skin or mucous membranes. Overproduction of the vasodilator bradykinin (BK) is an important...
