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Pretreatment with platelet-rich plasma protects against ischemia–reperfusion induced flap injury by deactivating the JAK/STAT pathway in mice
BackgroundIschemia–reperfusion (I/R) injury is a major cause of surgical skin flap compromise and organ dysfunction. Platelet-rich plasma (PRP) is an...
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Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells
Advancement of stem cell-based treatment will involve next-generation approaches to enhance therapeutic efficacy which is often modest, particularly...
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Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris
Acne vulgaris is a common chronic skin disorder presenting with comedones, cystic structures forming within the distal hair follicle, and in most...
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O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
ObjectiveIncreased O -linked β- N -acetylglucosamine ( O -GlcNAc) stimulation has been reported to protect against sepsis associated mortality and...
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The Anorectic Phenotype of the anx/anx Mouse Is Associated with Hypothalamic Dysfunction
The anorectic anx/anx mouse, mimicking the core characteristics of anorexia nervosa (AN), i.e., reduced food intake, emaciation, and premature death,...
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Deciphering the similarities and disparities of molecular mechanisms behind respiratory epithelium response to HCoV-229E and SARS-CoV-2 and drug repurposing, a systems biology approach
PurposeIdentifying the molecular mechanisms behind SARS-CoV-2 disparities and similarities will help find new treatments. The present study...
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Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance
Homologous recombination (HR) repair deficiency impairs the proper maintenance of genomic stability, thus rendering cancer cells vulnerable to loss...
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Sphingolipids: A Roadmap from Biomarker Identification to Clinical Application
Sphingolipids are a class of bioactive lipids that have recently gained paramount attention in the field of cancer biology. Sphingolipid metabolism...
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PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells
ObjectiveThe dysfunction of pulmonary microvascular endothelial cells (PMVECs) is one of the critical characteristics of acute lung injury/acute...
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Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndrome
BackgroundPrimary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by abnormal immune cell activation. This study aimed to...
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First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways
Hepatoblastoma stands as the most prevalent liver cancer in the pediatric population. Characterized by a low mutational burden, chromosomal and...
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Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning
The amygdala is a brain region primarily associated with emotional response. The use of genetic markers and single-cell transcriptomics can provide...
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Molecular Correlates of Hemorrhage and Edema Volumes Following Human Intracerebral Hemorrhage Implicate Inflammation, Autophagy, mRNA Splicing, and T Cell Receptor Signaling
Intracerebral hemorrhage (ICH) and perihematomal edema (PHE) volumes are major determinants of ICH outcomes as is the immune system which plays a...
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Post-translational Mechanisms of Zinc Signalling in Cancer
Three groups of proteins are actively involved in the control of intracellular zinc, consisting of ZIP channels (SLC39A), ZnT transporters (SLC30A),...
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In vivo functional screening for systems-level integrative cancer genomics
With the genetic portraits of all major human malignancies now available, we next face the challenge of characterizing the function of mutated genes,...
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RETRACTED ARTICLE: Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1
Ovarian cancer is a common human malignancy of the female reproductive system. However, chemotherapy has been proven to have limited effectiveness in...
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Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming
BackgroundCancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers...
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Viren mit doppelsträngigem DNA-Genom
Es sind viele Viren mit einem doppelsträngigen DNA-Genom bekannt, die Wirbeltiere infizieren. Die Menschen und Säugetiere infizierenden Viren werden...
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Riluzole Attenuates L-DOPA-Induced Abnormal Involuntary Movements Through Decreasing CREB1 Activity: Insights from a Rat Model
Chronic administration of L-DOPA, the first-line treatment of dystonic symptoms in childhood or in Parkinson’s disease, often leads to the...
