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Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway
BackgroundMaintaining the repair phenotype of denervated Schwann cells in the injured distal nerve is crucial for promoting peripheral nerve...
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LCM-Seq for Retinal Cell Layer-Specific Responses During Optic Nerve Regeneration
LCM-seq is a powerful tool for gene expression analysis from individual or groups of cells that can be spatially isolated. Within the visual system,...
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Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor
Regeneration of the neuromuscular junction (NMJ) leverages on extensive exchange of factors released from motor axon terminals (MATs), muscle fibers...
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Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury
BackgroundPeripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and...
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Prospects for Nerve Regeneration and Gene Therapy in the Treatment of Traumatic Brain Injury
Traumatic brain injury (TBI) is a prevalent neurological disorder and a leading cause of death and disability worldwide. The high mortality rates...
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Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury
The prognosis of peripheral nerve injury (PNI) is usually poor, and currently, there is no effective treatment for PNI. Studies have shown that...
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NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve, fail to regenerate their axons after injury. The...
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The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
Schwann cell (SC) myelination is a pivotal event in the normal physiological functioning of the peripheral nervous system (PNS), where myelination is...
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Optic Nerve Crush Injury in Rodents to Study Retinal Ganglion Cell Neuroprotection and Regeneration
Optic nerve crush injury is a useful model for studying the response of central nervous system neurons (CNS) to injury. A particular focus of this...
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Axon Regeneration Methods and Protocols
This volume covers a wide range of approaches utilized to decipher cellular and molecular mechanisms that contribute to successful nerve regeneration...
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Types of Short-Duration Electrical Stimulation-Induced Efficiency in the Axonal Regeneration and Recovery: Comparative in Vivo Study in Rat Model of Repaired Sciatic Nerve and its Tibial Branch after Transection Injury
The restoration of adequate function and sensation in nerves following an injury is often insufficient. Electrical stimulation (ES) applied during...
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Profiling Dynamic Changes in DNA Accessibility During Axon Regeneration After Optic Nerve Crush in Adult Zebrafish
A time-course series utilizing assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) can be used to detect changes in...
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Mature but not develo** Schwann cells promote axon regeneration after peripheral nerve injury
Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), develo** SCs might be able to...
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Spinal Cord Regeneration
Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other achievements in neuroscience would have such a tremendous...
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Genes in Axonal Regeneration
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its...
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Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury
BackgroundPeripheral nerve injuries are accompanied by inflammatory reactions, over-activation of which may hinder recovery. Among pro-inflammatory...
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Nerve-specific extracellular matrix hydrogel promotes functional regeneration following nerve gap injury
Nerve transection requires surgical intervention to restore function. The standard of care involves coaptation when a tension-free repair is...
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The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review
Peripheral neuropathies caused by the peripheral nervous system (PNS) damage can occur due to trauma and other disorders. They present as altered...
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Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration
Axons of adult neurons in the mammalian central nervous system generally fail to regenerate by themselves, and few if any therapeutic options exist...
