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T Cell: Primary Culture from Peripheral Blood
Peripheral blood mononuclear cells (PBMCs) can be used to assess cell-mediated immunity in general or via antigen-specific stimulation to detect...
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The effect of UV-protected ethylene vinyl acetate (EVA) bags on the physicochemical stability of pediatric parenteral nutrition admixtures
BackgroundThe safe administration of parenteral admixtures should be considered under the headings of physical and chemical stability. Vitamins are...
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Lyophilization of High-Concentration Protein Formulations
High-concentration protein formulations are in the focus of current pharmaceutical development because the required therapeutic doses of biologics,...
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Proteomic Analysis of Cerebral Cortex Extracts from Sus scrofa with Induced Hemorrhagic Stroke
Cerebrovascular diseases, including stroke and micro stroke, are the main causes of death in contemporary society. Hemorrhagic stroke is the fast...
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Magnetic and Acoustically Active Microbubbles Loaded with Nucleic Acids for Gene Delivery
Targeted gene or drug delivery aims to locally accumulate the active agent and achieve the maximum local therapeutic effect at the target site while...
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Interferons and Interleukins
Endogenous interferons and interleukins, major protagonists of our defense system, act in a concerted way within the immune system to defend against,...
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High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage
Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles...
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Introduction into Novel Constructs
New biologic molecules—such as mAb-derived formats, nanobodies, bispecifics, and fusion proteinsFusion proteins —are quite diverse and come along...
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Isolation of Exosomes for the Purpose of Protein Cargo Analysis with the Use of Mass Spectrometry
Exosomes are intercellular messengers with a high potential for diagnostic and therapeutic utility. It is believed that exosomes present in body...
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Absolute oral bioavailability of selexipag, a novel oral prostacyclin IP receptor agonist
PurposeThe aim of this single-center, open-label study was to assess the absolute bioavailability of an oral (tablet) versus intravenous (i.v.)...
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Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism
In amyotrophic lateral sclerosis (ALS), motor neuron degeneration is associated with systemic metabolic impairment. However, the evolution of...
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Aerodynamic Droplet Stream Expansion for the Production of Spray Freeze-Dried Powders
In spray freeze-srying (SFD), a solution is sprayed into a refrigerant medium, frozen, and subsequently sublimation dried, which allows the...
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The Use of Technetium-99m for Intravital Tracing of Transplanted Multipotent Stromal Cells
We studied the possibility of in vivo tracing of multipotent mesenchymal stromal cells labeled with a radiophermaceutic preparation based on...
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Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism
In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic impairment and neuroinflammation....
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Enzymatic Modification of 5′-Capped RNA and Subsequent Labeling by Click Chemistry
The combination of enzymatic modification and bioorthogonal click chemistry provides a powerful approach for site-specific labeling of different...
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Effects of Cyanotoxins: Sea and Freshwater Toxins
Cyanobacteria produce a wide range of toxins with different chemical composition and molecular targets. Cyanobacterial neurotoxins comprise a variety...
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Effects of Cyanotoxins: Sea and Freshwater Toxins
Cyanobacteria produce a wide range of toxins with different chemical composition and molecular targets. Cyanobacterial neurotoxins comprise a variety...
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Application of QbD Principles to Late-Stage Formulation Development for Biological Liquid Products
Quality by Design (QbD) is a science- and risk-based approach to drug product development. While many of the same principles have been historically...
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Optimization of the Fine Particle Fraction of a Lyophilized Lysozyme Formulation for Dry Powder Inhalation
PurposeA new dry powder inhalation technology creates inhalable particles from a coherent lyophilized bulk at the time of inhalation. The aim of this...
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Identification of black market products and potential do** agents in Germany 2010–2013
PurposeThe desire to increase the athletic performance, to ‘optimize’ an individual’s appearance, and to complement but also to arguably substitute...
