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Inactivation of cell-free HIV-1 by designing potent peptides based on mutations in the CD4 binding site
Human immunodeficiency virus type 1 (HIV-1) is a major global health problem, with over 38 million people infected worldwide. Current anti-HIV-1...
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In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV
Human Immunodeficiency Virus (HIV) is one of the world's most significant public health issues. HIV become severe in the COVID pandemic. Scientists...
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Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV
Since publishing our original reports on the safety and immunogenicity of a polyvalent DNA prime-protein boost HIV vaccine (PDPHV) which elicited...
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Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
BackgroundBone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks the release of HIV-1...
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Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans
Adjuvants can alter the magnitude, characteristics, and persistence of the humoral response to protein vaccination. HIV vaccination might benefit...
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Leveraging antigenic seniority for maternal vaccination to prevent mother-to-child transmission of HIV-1
The development of a maternal HIV vaccine to synergize with current antiretroviral drug prophylaxis can overcome implementation challenges and...
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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators
BackgroundWe previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and...
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Neuronal Cytoskeleton and HIV-Mediated Neurodegeneration
Human immunodeficiency virus (HIV) does not infect neurons, yet dendritic simplifications and loss of synapses are seen in different brain areas of...
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Helix-A peptide prevents gp120-mediated neuronal loss
AimThe human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have...
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Method for the Enrichment of N6-Methyladenosine-Modified Cellular and HIV-1 RNA
N6-methyladenosine (m6A) modification of RNA is an important area in studying viral replication, cellular responses, and host immunity. HIV-1 RNA...
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On the irrationality of rational design of an HIV vaccine in light of protein intrinsic disorder
The lack of progress in finding an efficient vaccine for a human immunodeficiency virus (HIV) is daunting. In fact, this search has spanned nearly...
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Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were...
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Synergistic Effect and Mechanism of Apoptosis Induction by Morphine and the HIV-1gp120V3 Loop in Hippocampal Neurons
AbstractHIV-associated neurocognitive disorders (HAND) are a collective name for neurological disorders associated with HIV-1 infection. The...
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NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive...
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Production and Study of Immunochemical Properties of Stabilized Env Trimer of Recombinant Form CRF63_02A6 of HIV-1
Stabilized trimers of the HIV-1 envelope glycoprotein Env are capable of inducing a potent and sustained broadly neutralizing antibody response in...
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Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings with controlled tunable release profiles for multiple active drugs
We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for...
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Co-receptor signaling in the pathogenesis of neuroHIV
The HIV co-receptors, CCR5 and CXCR4, are necessary for HIV entry into target cells, interacting with the HIV envelope protein, gp120, to initiate...
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The chemokine receptor CCR5: multi-faceted hook for HIV-1
Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by...
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HIV-1 restriction by SERINC5
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a...
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Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies....
