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Lymphomas of Central Nervous System
Central nervous systemCentral nervous system (CNS) (CNS) lymphoma consists of primary central nervous system lymphomaPrimary Central Nervous System...
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Deferoxamine Prevents Neonatal Posthemorrhagic Hydrocephalus Through Choroid Plexus-Mediated Iron Clearance
Posthemorrhagic hydrocephalus occurs in up to 30% of infants with high-grade intraventricular hemorrhage and is associated with the worst...
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The role of astrocytes in the glymphatic network: a narrative review
To date, treatment of Central Nervous System (CNS) pathology has largely focused on neuronal structure and function. Yet, revived attention towards...
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Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
IntroductionPosthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and...
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Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4...
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The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
BackgroundGerminal matrix intraventricular hemorrhage (GM-IVH) is associated with cerebro-cerebellar damage in very preterm infants, leading to...
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Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture
BackgroundGerminal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from...
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Extremely Preterm Infants with a Near-total Absence of Cerebellum: Usefulness of Quantitative Magnetic Resonance in Predicting the Motor Outcome
This study aims to evaluate in extremely premature infants the severity of brain structural injury causing total absence or near-total absence of...
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Intranasal Drug Delivery After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) accounts for 10–15% of strokes and is associated with high mortality and disability rates. Studies in animal models...
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Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations
Genetic alterations in COL4A2 are less common than those of COL4A1 and their fetal phenotype has not been described to date. We describe a...
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Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome
Primary Sjögren’s syndrome (pSS) is an autoimmune disease that primarily affects the exocrine glands and is mainly characterized by sicca symptoms of...
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Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils
BackgroundThrombin has been implicated in playing a role in hydrocephalus development following intraventricular hemorrhage (IVH). However, the...
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The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial...
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Zinc and selenium attenuate quaternary heavy metal mixture-induced testicular damage via amplification of the antioxidant system, reduction in metal accumulation, inflammatory and apoptotic biomarkers
Heavy metals (HMs) such as cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg) are highly toxic elements. They are often found together in nature...
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A year in review: brain barriers and brain fluids research in 2022
This aim of this editorial is to highlight progress made in brain barrier and brain fluid research in 2022. It covers studies on the blood-brain,...
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Comprehensive CCM3 Mutational Analysis in Two Patients with Syndromic Cerebral Cavernous Malformation
Cerebral cavernous malformation (CCM) is a vascular disease that affects the central nervous system, which familial form is due to autosomal dominant...
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Consequences for Cerebellar Development of Very Premature Birth
Premature birth is a major public health problem. It is associated with damage to the develo** nervous system and it is now becoming clear that the...
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Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection...
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Fetal Brain Damage in Human Fetuses with Congenital Cytomegalovirus Infection: Histological Features and Viral Tropism
Human cytomegalovirus (HCMV) causes congenital neurological lifelong disabilities. To date, the neuropathogenesis of brain injury related to...
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The Role of Thrombin in Brain Injury After Hemorrhagic and Ischemic Stroke
Thrombin is increased in the brain after hemorrhagic and ischemic stroke primarily due to the prothrombin entry from blood either with a hemorrhage...
