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Quantitative susceptibility map** from basal ganglia and related structures: correlation with disease severity in progressive supranuclear palsy
ObjectiveWe examined whether mean magnetic susceptibility values from deep gray matter structures in patients with progressive supranuclear palsy...
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Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity
BackgroundThe variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental...
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TYK2 single-nucleotide variants associated with the severity of COVID-19 disease
Coronavirus disease 2019 (COVID-19) is a lethal disease caused by the coronavirus SARS-CoV-2, which can result in a broad clinical spectrum of...
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HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients
BackgroundEven after 3 years from SARS-CoV-2 identification, COVID-19 is still a persistent and dangerous global infectious disease. Significant...
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Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity
BackgroundChronic kidney disease (CKD) is a severe public health problem associated with a disordered gut microbiome. However, the functional...
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T-cell dysregulation is associated with disease severity in Parkinson’s Disease
The dysregulation of peripheral immunity in Parkinson’s Disease (PD) includes changes in both the relative numbers and gene expression of T cells....
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Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
BackgroundThe recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in...
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A genome-wide association analysis of loss of ambulation in dystrophinopathy patients suggests multiple candidate modifiers of disease severity
The major determinant of disease severity in Duchenne muscular dystrophy (DMD) or milder Becker muscular dystrophy (BMD) is whether the dystrophin...
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Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Mental imagery is the mental re-creation of perceptual experiences, events and scenarios, and motor acts. In our previous study, we assessed whether...
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Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson’s disease
Diagnosis of essential tremor (ET) at an early stage can be difficult, especially when distinguishing it from healthy controls (HCs) and Parkinson’s...
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Monitoring of optic sheath diameter during acute migraine attack: an objective criteria for the severity of disease
BackgroundThe etiology of migraine can be complex and multifactorial but not clear, also, intracranial pressure has been already associated with...
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The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders, but there is no metric that predicts disease severity over time. We...
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Serum neurofilament light chain and initial severity of neurological disease predict the early neurological deterioration in Wilson’s disease
BackgroundIn Wilson’s disease (WD), early neurological deterioration after treatment initiation is associated with poor outcomes; however, data on...
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Predictors of relapse severity in multiple sclerosis
BackgroundThe severity of relapses is one of the determinants of residual disability in multiple sclerosis (MS), contributing to the final...
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Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia
BackgroundThrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor...
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Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients
BackgroundT cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T...
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Scoring for Hemorrhage Severity in Traumatic Injury
Severity scores have long been used for the classification or stratification of patients for clinical care and in the evaluation of outcomes. Such...
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Performance on the balloon analogue risk task and anticipatory response inhibition task is associated with severity of impulse control behaviours in people with Parkinson’s disease
Dopamine agonist medication is one of the largest risk factors for development of problematic impulse control behaviours (ICBs) in people with...
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Involvement of IL-17 A/IL-17 Receptor A with Neutrophil Recruitment and the Severity of Coronary Arteritis in Kawasaki Disease
PurposeTo assess the role of the interleukin (IL)-17 A/IL-17 receptor A (IL-17RA) in Kawasaki disease (KD)-related coronary arteritis (CA).
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Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration
BackgroundCortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar...
