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Role of the endothelial reverse mode sodium-calcium exchanger in the dilation of the rat middle cerebral artery during hypoosmotic hyponatremia
A decrease in serum sodium ion concentration below 135 mmol L −1 is usually accompanied by a decrease in plasma osmolality (hypoosmotic hyponatremia)...
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Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and...
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Spatial and temporal aspects of neuronal calcium and sodium signals measured with low-affinity fluorescent indicators
Low-affinity fluorescent indicators for Ca 2+ or Na + allow measuring the dynamics of intracellular concentration of these ions with little...
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Critical Pronociceptive Role of Family 2 Voltage-Gated Calcium Channels in a Novel Mouse Model of HIV-Associated Sensory Neuropathy
Some people living with HIV present painful sensory neuropathy (HIV-SN) that is pharmacoresistant, sex-associated, and a major source of morbidity....
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Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice
In Parkinson’s disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) degenerate before their cell bodies....
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Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging
Endo-lysosomes are membrane-bound acidic organelles that are involved in endocytosis, recycling, and degradation of extracellular and intracellular...
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The Role of Striatal Cav1.3 Calcium Channels in Therapeutics for Parkinson’s Disease
Parkinson’s disease (PD) is a relentlessly progressive neurodegenerative disorder with typical motor symptoms that include rigidity, tremor, and...
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Dietary calcium phosphate strongly impacts gut microbiome changes elicited by inulin and galacto-oligosaccharides consumption
BackgroundFructo-oligosaccharides (FOS), inulin, and galacto-oligosaccharides (GOS) are widely recognized prebiotics that profoundly affect the...
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Excitotoxicity and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive and selective death of motor neurons...
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Calcium Channel Splice Variants and Their Effects in Brain and Cardiovascular Function
Calcium ions serve as an important intracellular messenger in many diverse pathways, ranging from excitation coupling in muscles to neurotransmitter...
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Simulation Strategies for Calcium Microdomains and Calcium Noise
In this article, we present an overview of simulation strategies in the context of subcellular domains where calcium-dependent signaling plays an...
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Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying...
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Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling
The cellular and molecular mechanisms that drive neurodegeneration remain poorly defined. Recent clinical trial failures, difficult diagnosis,...
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Expression of phosphate and calcium transporters and their regulators in parotid glands of mice
The concentration of inorganic phosphate (Pi) in plasma is under hormonal control, with deviations from normal values promptly corrected to avoid...
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