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Calcium Channel Splice Variants and Their Effects in Brain and Cardiovascular Function

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Ion Channels in Biophysics and Physiology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1349))

Abstract

Calcium ions serve as an important intracellular messenger in many diverse pathways, ranging from excitation coupling in muscles to neurotransmitter release in neurons. Physiologically, the concentration of free intracellular Ca2+ is up to 10,000 times less than that of the extracellular concentration, and increases of 10- to 100-fold in intracellular Ca2+ are observed during signaling events. Voltage-gated calcium channels (VGCCs) located on the plasma membrane serve as one of the main ways in which Ca2+ is able to enter the cell. Given that Ca2+ functions as a ubiquitous intracellular messenger, it is imperative that VGCCs are under tight regulation to ensure that intracellular Ca2+ concentration remains within the physiological range. In this chapter, we explore VGCCs’ inherent control of Ca2+ entry as well as the effects of alternative splicing in CaV2.1 and posttranslational modifications of CaV1.2/CaV1.3 such as phosphorylation and ubiquitination. Deviation from this physiological range will result in deleterious effects known as calcium channelopathies, some of which will be explored in this chapter.

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Authors and Affiliations

  1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Sean Qing Zhang Yeow, Kelvin Wei Zhern Loh & Tuck Wah Soong

  2. NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore

    Sean Qing Zhang Yeow, Kelvin Wei Zhern Loh & Tuck Wah Soong

  3. Healthy Longevity Translational Research Programme and Cardiovascular Disease Translational Research Programme, National University of Singapore, Singapore, Singapore

    Tuck Wah Soong

  4. Neurobiology Programme, Life Science Institute, National University of Singapore, Singapore, Singapore

    Tuck Wah Soong

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    Lei Zhou

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Yeow, S.Q.Z., Loh, K.W.Z., Soong, T.W. (2021). Calcium Channel Splice Variants and Their Effects in Brain and Cardiovascular Function. In: Zhou, L. (eds) Ion Channels in Biophysics and Physiology. Advances in Experimental Medicine and Biology, vol 1349. Springer, Singapore. https://doi.org/10.1007/978-981-16-4254-8_5

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