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Comparison of Non B-Ig and B-Ig
Immunoglobulin (Ig) has been widely acknowledged to be produced solely by B-lineage cells. However, growing evidence has demonstrated the expression...
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Marine-derived microbes and molecules for drug discovery
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many...
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Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations
PurposesSTAT1 is a transduction and transcriptional regulator that functions within the classical JAK/STAT pathway. In addition to chronic...
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Generation of VNAR Libraries from Immunized Sharks and Selection of Target-Specific Clones
Cartilaginous fishes (sharks, skates, rays, and chimeras) are the most phylogenetically distant lineage relative to mammals in which somatically...
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A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized...
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Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus
BackgroundInfections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in...
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Antibody Clustering and 3D Modeling for Neurodegenerative Diseases
Antibodies, or immunoglobulins, belong to the “gamma globulin” protein group and can be found mainly in the blood of vertebrates. Antibodies...
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Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to activate large numbers of T cells simultaneously. SAgs...
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Inadequate Activation of γδT- and B-cells in Patient with Wiskott-Aldrich Syndrome (WAS) Portrayed by TRG and IGH Repertoire Analyses
Patients with Wiskott-Aldrich syndrome (WAS) harbor mutations in the WAS gene and suffer from immunodeficiency, microthrombocytopenia, and eczema....
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T-cell immunity induced and reshaped by an anti-HPV immuno-oncotherapeutic lentiviral vector
We recently developed an immuno-oncotherapy against human papillomavirus (HPV)-induced tumors based on a lentiviral vector encoding the Early E6 and...
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Evolution of immunogenetic components encoding ultralong CDR H3
The genomes of most vertebrates contain many V, D, and J gene segments within their Ig loci to construct highly variable CDR3 sequences through...
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Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
BackgroundThe spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned...
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Engineered Therapeutic Antibody Against SARS-CoV-2
Purpose of ReviewThe success and failure of therapeutic antibodies against SARS-CoV-2 offer a lesson on therapeutic antibody design and development.
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Costimulatory receptors in the channel catfish: CD28 family members and their ligands
The CD28-B7 interaction is required to deliver a second signal necessary for T-cell activation. Additional membrane receptors of the CD28 and B7...
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Predictability of B cell clonal persistence and immunosurveillance in breast cancer
B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well...
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IMGT/3Dstructure-DB: T-Cell Receptor TR Paratope and Peptide/Major Histocompatibility pMH Contact Sites and Epitope
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as...
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Antibody Affinity Maturation Using Computational Methods: From an Initial Hit to Small-Scale Expression of Optimized Binders
Nanobodies (VHHs) are engineered fragments of the camelid single-chain immunoglobulins. The VHH domain contains the highly variable segments...
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Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of patients (<10%) with MG, have...
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Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies
Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the...
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The Advent of Precision Immunology : Immunogenetics at the Center of Immune Cell Analysis in Health and Disease
Adaptive immune cells (i.e., lymphocytes of the B and T lineage) are equipped with unique antigen receptors, which collectively form a highly diverse...