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Weighted burden analysis of rare coding variants in 470,000 exome-sequenced UK Biobank participants characterises effects on hyperlipidaemia risk
A previous study of 200,000 exome-sequenced UK Biobank participants investigating the association between rare coding variants and hyperlipidaemia...
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Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation
BackgroundThe blood-brain barrier (BBB) is pivotal for the maintenance of brain homeostasis and it strictly regulates the cerebral transport of a...
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Biological Markers of Insulin Sensitivity Links with Dietary Antioxidant
Obesity plays an essential role in develo** chronic conditions such as metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), and...
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Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
Obesity is an established risk factor for several human cancers. Given the association between excess body weight and cancer, the increasing rates of...
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Mesenteric Organ Lymphatics in Abdominal Inflammation
The understanding of the lymphatic vasculature lags far behind that of the blood vasculature, despite both belonging to vascular circulatory systems....
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Effect of mountain ultra-marathon running on plasma angiopoietin-like protein 4 and lipid profile in healthy trained men
PurposeAngiopoietin-like protein 4 (ANGPTL4) regulates lipid metabolism by inhibiting lipoprotein lipase activity and stimulating lipolysis in...
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Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Metabolic reprogramming, a hallmark of cancer, allows cancer cells to adapt to their specific energy needs. The Warburg effect benefits cancer cells...
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Analysis of the Involvement of Susceptibility Genes to Coronary Heart Disease in Implementation Signaling and Metabolic Pathways
AbstractCoronary heart disease (CHD) is a common pathology, and its development is mediated by a large number of genetic factors, environmental...
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Association of Genotypes of ANGPTL3 with Vitamin D and Calcium Concentration in Cardiovascular Disease
One of the leading causes of mortality worldwide is cardiovascular disease, which is influenced by some variables, including calcium and vitamin D....
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Identification and validation of a six-gene signature associated with glycolysis to predict the prognosis of patients with cervical cancer
BackgroundCervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer...
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DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia
BackgroundEpigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids....
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Establishing a prognostic model based on immune-related genes and identification of BIRC5 as a potential biomarker for lung adenocarcinoma patients
BackgroundLung adenocarcinoma (LUAD) is an extraordinarily malignant tumor, with rapidly increasing morbidity and poor prognosis. Immunotherapy has...
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Hypoxia-Regulated Gene Expression and Metastasis
Mammalian cells have adopted mechanisms to regulate cellular oxygen levels for the maintenance of the cellular homeostatic balance. “Hypoxia” states...
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Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3–L1 cells
We previously synthesized two retinoid X receptor (RXR) agonists, 4′-hydroxy-3′-propyl-[1,1′-biphenyl]-3-propanoic acid ethyl ester (4′OHE) and...
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RNA-seq reveals differentially expressed lncRNAs and circRNAs and their associated functional network in HTR-8/Svneo cells under hypoxic conditions
Placental hypoxia is hazardous to maternal health as well as fetal growth and development. Preeclampsia and intrauterine growth restriction are...
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Lymphatic Vasculature and Hair Follicle Regeneration
Introduction: When fluids build up in the skin, it is the function of lymphatic vessels (LV) that allows their proper drainage. LV exert vital roles...
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PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer
BackgroundAberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that...
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High Expression of Angiopoietin-like Protein 4 in Advanced Colorectal Cancer and its Association with Regulatory T Cells and M2 Macrophages
Colorectal cancer (CRC) is one of the most aggressive tumours in the human digestive system. Most CRC patients have poor prognosis due to metastasis...
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Distal Onco-sphere: Organotrophic Metastasis
In order for CTCs to find a suitable soil for its growth, CTCs need to assess the distal onco-sphere for suitability in terms of secreted factors,...
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ANGPTL3 is a novel HDL component that regulates HDL function
BackgroundAngiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous...
