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Distal Onco-sphere: Organotrophic Metastasis

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Tumor Ecosystem

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Abstract

In order for CTCs to find a suitable soil for its growth, CTCs need to assess the distal onco-sphere for suitability in terms of secreted factors, inflammation, and metabolic changes in the new environment. In this chapter, we discuss on the interesting fact that the tumor cells secrete various factors to create a different distal onco-sphere, leading to predisposition of CTCs to metastasize specifically towards certain organs. We also discuss how to host builds in its protective defense mechanism to counter these organotrophic metastasis events.

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Phei Er Saw & Erwei Song

  2. Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Foshan, China

    Phei Er Saw & Erwei Song

  3. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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  1. Phei Er Saw
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  2. Erwei Song
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  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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Saw, P.E., Song, E. (2023). Distal Onco-sphere: Organotrophic Metastasis. In: Song, E. (eds) Tumor Ecosystem. Springer, Singapore. https://doi.org/10.1007/978-981-99-1183-7_16

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