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Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...
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A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy
Free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS) cause cellular damage and contribute to thromboembolic diseases...
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Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS)
Depression, considered the most prevalent neuropsychiatric disorder, is multifactorial and complex. Oxidative stress and inflammation significantly...
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An insight into the therapeutic effects of isoliquiritigenin in breast cancer
Breast cancer ranks as the most widespread malignant condition in women, emerging as a primary contributor to mortality. The primary challenges in...
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Mechanisms involved in the antidepressant-like action of orally administered 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) in male and female mice
RationaleThe compound 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) has recently been shown to inhibit in vitro acetylcholinesterase...
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FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal apoptosis via mitochondrial autophagy in the context of cerebral...
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Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis
Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression...
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DNA methylation, but not microRNA expression, is affected by in vitro THC exposure in bovine granulosa cells
BackgroundA global increase in cannabis use has led to questions about its effects on fertility. The rise in consumption amongst women of...
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Unraveling the noncoding RNA landscape in glioblastoma: from pathogenesis to precision therapeutics
Glioblastoma (GBM) is an aggressive type IV brain tumor that originates from astrocytes and has a poor prognosis. Despite intensive research,...
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“Cardiac glycosides”—quo vaditis?—past, present, and future?
Up to date, digitalis glycosides, also known as “cardiac glycosides”, are inhibitors of the Na + /K + -ATPase. They have a long-standing history as drugs...
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Activation AMPK in Hypothalamic Paraventricular Nucleus Improves Renovascular Hypertension Through ERK1/2-NF-κB Pathway
Hypertension is a globally prevalent disease, but the pathogenesis remains largely unclear. AMP-activated protein kinase (AMPK) is a...
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GC-MS analysis and pharmacological potentiality of Lasia spinosa (L.) Thwaites leaves and fruit extracts: an in vitro and in silico studies
Lasia spinosa ( L. spinosa ) is widely used in Asian countries for treating various diseases and as a vegetable, yet its bioactive properties remain...
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MicroRNA-143 overexpression enhances the chemosensitivity of A172 glioblastoma cells to carmustine
As an aggressive malignancy, glioblastoma multiforme (GBM) is the most common type of brain tumor. The existing treatments have shown limited...
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Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous...
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Measuring and Understanding Market Exclusivity Length for New Prescription Drugs in France, Australia, and the USA
BackgroundOriginator drug manufacturers use several strategies to delay generic competition in the USA, but it remains unclear whether this results...
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Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multilateral agencies. The...
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Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2
Ribavirin ( 1 ) esters 4–36 have been synthesized and tested for their anti-inflammatory and anti-viral properties against SARS-CoV-2. The impaired...
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Effects of active vitamin D analogs and calcimimetic agents on PTH and bone mineral biomarkers in hemodialysis patients with SHPT: a network meta-analysis
ObjectiveActive vitamin D analogs and calcimimetic agents are primary drugs for patients with secondary hyperparathyroidism. Due to the different...
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Identification of acrolein as a novel diagnostic odor biomarker for 1,2,3-trichloropropane-induced hepatotoxicity in Sprague Dawley rats
Body odor is considered a diagnostic indicator of various infectious and chronic diseases. But, few studies have examined the odor markers for...
