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DSP-6745, a novel 5-hydroxytryptamine modulator with rapid antidepressant, anxiolytic, antipsychotic and procognitive effects
BackgroundCurrent treatment of major depressive disorder is facing challenges, including a low remission rate, late onset of efficacy, and worsening...
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Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse
Mesolimbic dopamine (DA) transmission is believed to play a critical role in mediating reward responses to drugs of abuse, including alcohol (EtOH)....
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The Role of Anatomic Connectivity in Inhibitory Control Revealed by Combining Connectome-based Lesion-symptom Map** with Event-related Potentials
Inhibitory control refers to the ability to suppress cognitive or motor processes. Current neurocognitive models indicate that this function mainly...
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Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities
Age and depression may interact to produce a “double jeopardy” for cognitive impairment, and executive functioning, in cognitively unimpaired aging....
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Fatigue in Multiple Sclerosis: A Resting-State EEG Microstate Study
Fatigue affects approximately 80% of people with Multiple Sclerosis (PwMS) and can impact several domains of daily life. However, the neural...
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Sleep disturbances are associated with greater healthcare utilization in children with autism spectrum disorder
BackgroundSleep disturbances are frequently reported in children with autism spectrum disorder (ASD) and are associated with the severity of...
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Obstructive Sleep Apnea in an Infant with Suspected Congenital Leptin Hormone Receptor Deficiency
An 8-month-old female child, born of a consanguineous marriage, presented to the Paediatrics department, with complaints of excessive weight gain,...
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Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
RationaleAlzheimer’s disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, memory and intellectual...
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Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
RationaleFlavors can alter the orosensory properties of tobacco products. Specifically, flavors can serve as an oral cue for smokeless tobacco...
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Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
RationaleMotivational dysfunctions related to effort exertion are common in psychiatric disorders. Dopamine systems regulate exertion of effort and...
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Chronic Caffeine Consumption, Alone or Combined with Agomelatine or Quetiapine, Reduces the Maximum EEG Peak, As Linked to Cortical Neurodegeneration, Ovarian Estrogen Receptor Alpha, and Melatonin Receptor 2
RationaleEvidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) or quetiapine...
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Saudi Clinical Psychologists’ Competence in Sleep Disorders Management: A Comprehensive Perspective
Sleep disorders comprise a range of medical conditions that interfere with regular sleep patterns. Despite the fact that clinical psychologists have...
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A Comparison of a Wrist-Worn Portable Device (WatchPAT 200)™ with In-Lab Polysomnography for the Diagnosis of Obstructive Sleep Apnea
ObjectivesTo assess the sensitivity of WatchPAT 200 for the diagnosis of moderate-to-severe OSA and diagnosis of OSA (any severity) using in-lab...
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Effect of exercise duration on toluene-induced locomotor sensitization in mice: a focus on the Renin Angiotensin System
RationaleExercise attenuates addictive behavior; however, little is known about the contribution of exercise duration to this positive effect. The...
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Functional and Effective Connectivity Underlying Semantic Verbal Fluency
Semantic verbal fluency (SVF) impairment is present in several neurological disorders. Although activation in SVF-related areas has been reported,...
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Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study
RationaleRecent reports have shown increased cannabis use among women, leading to growing concerns about cannabis use disorder (CUD). While there is...
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Sleep Quality of Heavy Vehicles’ Professional Drivers: An Analysis Based on Self-Perceived Feedback
IntroductionSleep is a crucial biological need for all individuals, being reparative on a physical and mental level. Driving heavy vehicles is a task...
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Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome
BackgroundIn the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic...
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Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats
RationaleMuscarinic receptor activity in the basolateral amygdala (BLA) is known to be involved in plasticity mechanisms that underlie emotional...
