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Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?
BackgroundThere is no consensus regarding the specific genes included in the homologous recombination repair (HRR) gene panel for identifying the HRR...
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Association between Ultradian Rhythms of Body Temperature in Small Mammals and Earth’s Crust Stress
Association was assessed between the data harvested by a long-baseline laser interference deformograph and the dynamics of body temperature (BT) in...
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Analysis of Toxicity of Recombinant Pneumolysin from Streptococcus pneumoniae
We studied toxicity of recombinant Streptococcus pneumoniae pneumolysin protein in experiments on mice and its cytopathogenic effect on cultures of...
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Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia
In adult male C57BL/6 mice with high (HR) and low (LR) resistance to hypoxia, morphological features of colon tumors and blood parameters were...
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Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy
We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the...
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Analysis of the Antimicrobial Activity of Epigallocatechin-3-Gallate (EGCG)
We studied antimicrobial activity of epigallocatechin-3-gallate (EGCG), a green tea polyphenolic catechin, and its combined use with ceftazidime...
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Assessment of the Sensitivity of Foodborne Cronobacter spp. Strains and Other Enterobacteria to Temperature Stresses and Chlorine-Containing Biocides
We examined the effects of elevated temperatures and biocides on survivability of food isolates of Cronobacter spp. ( C. sakazakii ) and concomitant...
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Characteristics of the Antitumor Effect of Doxorubicin and Pegylated Hyaluronidase on Models of Rat Brain Tumors
Hyaluronidase increases tissue permeability and diffusion of the extracellular fluid by cleaving hyaluronan, the primary component of the...
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TGFβ1 Regulates Cellular Composition of In Vitro Cardiac Perivascular Niche Based on Cardiospheres
The cardiac perivascular niche is a cellular microenvironment of a blood vessel. The principles of niche regulation are still poorly understood. We...
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Analysis of the Diversity and Functional Potential of Bacterial Communities in Tuberculomas
The dynamics of lung microbiota in tuberculosis remains poorly understood. Sequencing of variable regions of the 16S rRNA gene from surgically...
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Morphometric Indicators of Liver Acini of Deceased Newborns Depending on the Time of Death
We studied morphometric changes in the liver acini of dead newborns depending on the duration of the postmortem period. Autopsy samples of the liver...
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Comparative Morphological and Molecular Genetic Characteristics of Cell and Tissue Strains of Experimental Rat Glioma 10-17-2 (Astrid-17)
In order to obtain models of gliomas of varying degrees of malignancy, we performed morphological and molecular genetic study of a tissue strain of...
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Correlation between the Colony Phenotype and Amino Acid Sequence of the Variable Vaa Antigen in Clinical Isolates of Mycoplasma hominis
A new Mycoplasma hominis phenotype forming mini-colonies (MC) on agar and distinct from the phenotype forming typical colonies (TC) not only in size,...
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Effect of Short Peptides of Pregnancy-Specific β1-Glycoprotein on Differentiation of Human Regulatory T Cells In Vitro and on Their Cytokine Profile
Pregnancy-specific β1-glycoprotein (PSG), one of the most important proteins of pregnancy, has a pronounced immunosuppressive effect. Short peptides...
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New Aspects in the Study of Lactobacillus iners
A cultural microbiological study of the vaginal microbiota of patients of reproductive age was carried out to isolate the species Lactobacillus iners ...
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Experimental Modeling of Cranial Injury and Defect Reconstruction Using Superconstructive Polymers (PEEK)
Experimental model of resection craniotomy with subsequent reconstruction of the defect with a polymer implant enables comprehensive assessment of...
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Analysis of Methylome of Different Forms of Basal Cell Hyperplasia and Squamous Cell Metaplasia of Bronchial Epithelium
Squamous cell lung cancer (SCLC) occurs as a result of dysregenerative changes in the bronchial epithelium: basal cell hyperplasia (BCH), squamous...
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Tracking the Plasma C-Terminal Agrin Fragment as a Biomarker of Neuromuscular Decline in 18- to 87-Year-Old Men
ObjectivesPlasma C-terminal agrin-fragment-22 (CAF22), a breakdown product of neuromuscular junction, is a potential biomarker of muscle loss....
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Atypical Antiadrenergic Effect of Refralon as a Mechanism of High Antiarrhythmic Effectiveness
We studied the effect of Refralon on the electrophysiological properties of the supraventricular myocardium against the background of adrenergic...
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Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative
Compound L-36, a new derivative of 6 H -1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet...