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An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
DNA damage is one of the most important effects induced by chemical agents. We report a comparative analysis of DNA fragmentation on three different...
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Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation
Some previous researches have demonstrated that appropriate mechanical stimulation can enhance bone formation. However, most studies have employed...
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pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization
Forward addition/backward elimination (FABE) has been the standard for population pharmacokinetic model selection (PPK) since NONMEM® was introduced....
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Stability of Protein Pharmaceuticals: Recent Advances
There have been significant advances in the formulation and stabilization of proteins in the liquid state over the past years since our previous...
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Mucoadhesive Chitosan Composite Sponge as a Carrier for β-Sitosterol Cubosomes for Thermal Burn Treatment
Our study aimed to explore the potential of using nanostructured lipid carriers (NLCs) to enhance the topical administration of β-sitosterol, a...
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Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization...
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Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuating spontaneous recurrent...
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Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy
Vascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR) is frequently overexpressed in most of the cancers. It...
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Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
BackgroundIndividuals with Alzheimer’s disease (AD) often require many medications; however, these medications are dosed using regimens recommended...
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Naphthalimide Based Optical Probe for the Detection of Hydrazine in Water and Their Application in Test Strips and Silica Supported Material
A newly synthesized naphthalimide-based fluorophore probe NIA was used to detect hydrazine. This probe, based on the Gabriel mechanism exhibited a...
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Oleogels: Versatile Novel Semi-Solid System for Pharmaceuticals
Oleogels is a novel semi-solid system, focusing on its composition, formulation, characterization, and diverse pharmaceutical applications. Due to...
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Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2
The prevailing COVID-19 pandemic, triggered by the novel coronavirus SARS-CoV-2, stands as the predominant global health crisis of the decade,...
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Investigation of antimicrobial susceptibility patterns, risk factors and their impact on mortality in cancer patients at a tertiary care cancer hospital- A prospective study
BackgroundCancer patients are vulnerable to infections due to immunosuppression caused by cancer itself and its treatment. The emergence of...
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Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders
Neuropsychiatric and neurological disorders pose a significant global health burden, highlighting the need for innovative therapeutic approaches....
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Investigating the Impact of Blunt Force Trauma: A Probabilistic Study of Behind Armor Blunt Trauma Risk
Evaluating Behind Armor Blunt Trauma (BABT) is a critical step in preventing non-penetrating injuries in military personnel, which can result from...
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Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
Liver disease is a significant health burden globally and accounts for 4% of total deaths annually. Alcoholic liver disease (ALD) and...
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