8 Result(s)
within
bei Cai
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGeneration of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system
Recent advances in the study of the CRISPR/Cas9 system have provided a precise and versatile approach for genome editing in various species. However, the applicability and efficiency of this method in large an...
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Article
Open AccessEpidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessCorrection: Corrigendum: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessPathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population
Tuberculosis remains a global public health problem, and its immunopathogenesis is still poorly understood. In this study, 25 single nucleotide polymorphisms (SNPs) in the WNT pathway were evaluated in relatio...
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Article
Open AccessMultiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep
The CRISPR/Cas9 system provides a flexible approach for genome engineering of genetic loci. Here, we successfully achieved precise gene targeting in sheep by co-injecting one-cell-stage embryos with Cas9 mRNA ...
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Article
Open AccessGenetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population
Although the SLE risk gene loci of HLA-DR and HLA-DQ within the major histocompatibility complex (MHC) region has been gradually revealed by recent Genome-Wide Association studies (GWAS), the association of HLA-D...
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Open AccessMitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production
Mitochondria have a central position in innate immune response via the adaptor protein MAVS in mitochondrial outer membrane to limit viral replication by inducing interferon production. Here, we reported that ...
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Article
Open AccessThe establishment of neuron-specific enolase reference interval for the healthy population in southwest China
To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China’s healthy population by using the laboratory information system database. A total of 86957 periodic he...
