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Article
Open AccessLILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
Leukocyte Ig-like receptor B family 4 (LILRB4) as an immune checkpoint on myeloid cells is a potential target for tumor therapy. Extensive osteolytic bone lesion is the most characteristic feature of multiple ...
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Article
Correction to: LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells
We recently demonstrated that leukocyte Ig-like receptor 4 (LILRB4) expressed by monocytic acute myeloid leukemia (AML) cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular dom...
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Article
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Immune checkpoint blockade therapy has been successful in treating some types of cancer but has not shown clinical benefits for treating leukaemia1. This result suggests that leukaemia uses unique mechanisms to e...
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Article
Open AccessTranscription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer
Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer ...
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Article
Open AccessDifferential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype
E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis. E2F1 overexpression has been demonstrated in small...
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Article
p53 Status and Its Prognostic Role in Extrahepatic Bile Duct Cancer: A Meta-Analysis of Published Studies
The dysfunction of p53 is the most common genetic alteration in human cancer. A variety of studies have investigated the clinicopathologic correlation of p53 and its impact on patient survival in different typ...
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Article
Erythroid differentiation-related factor expression driven by effective promoter to ameliorate the anemia syndrome
The severity of β-thalassemia syndrome is associated with precipitation of the cytotoxic excessive free α-hemoglobin. We have established a therapy strategy aiming at stabilizing excessive free α-hemoglobin by de...
