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Article
Open AccessSystemic delivery of oncolytic herpes virus using CAR-T cells enhances targeting of antitumor immuno-virotherapy
Recent studies have indicated that combining oncolytic viruses with CAR-T cells in therapy has shown superior anti-tumor effects, representing a promising approach. Nonetheless, the localized delivery method o...
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Article
High temperature polyimide nanocomposites containing two-dimensional nanofillers for improved thermal stability and capacitive energy storage performance
Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated temperatures. However, the electrical deterioration ...
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Article
Open AccessDNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility
DNA replication in differentiated cells follows a defined program, but when and how it is established during mammalian development is not known. Here we show using single-cell sequencing, that late replicating...
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Article
Open AccessBCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
BCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory multiple myeloma (RRMM), however, the current preparation process for autolog...
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Article
Open AccessModulation of learning safety signals by acute stress: paraventricular thalamus and prefrontal inhibition
Distinguishing between cues predicting safety and danger is crucial for survival. Impaired learning of safety cues is a central characteristic of anxiety-related disorders. Despite recent advances in dissectin...
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Article
Open AccessIsostructural do** for organic persistent mechanoluminescence
Mechanoluminescence, featuring light emission triggered by mechanical stimuli, holds immense promise for diverse applications. However, most organic Mechanoluminescence materials suffer from short-lived lumine...
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Article
Open AccessOverexpression of the WRKY transcription factor gene NtWRKY65 enhances salt tolerance in tobacco (Nicotiana tabacum)
Salt stress severely inhibits plant growth, and the WRKY family transcription factors play important roles in salt stress resistance. In this study, we aimed to characterize the role of tobacco (Nicotiana tabacum
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Article
Open AccessDual-channel mechano-phosphorescence: a combined locking effect with twisted molecular structures and robust interactions
Organic mechanoluminescence materials, featuring dual emission and ultralong phosphorescence characteristics, exhibit significant potential for applications in real-time stress sensing, pressure-sensitive ligh...
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Article
A sequential linear programming (SLP) approach for uncertainty analysis-based data-driven computational mechanics
In this article, an efficient sequential linear programming algorithm (SLP) for uncertainty analysis-based data-driven computational mechanics (UA-DDCM) is presented. By assuming that the uncertain constitutiv...
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Article
Open AccessPrognosis and immunological characteristics of HDAC family in pan-cancer through integrative multi-omic analysis
The histone deacetylase (HDAC) family plays a significant role in a variety of biological processes related to cancer, such as metabolism and cancer progression, and recognized as a target of anti-cancer drugs...
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Article
Association between thyroid disorders and extra-thyroidal cancers, a review
Thyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invas...
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Article
Open AccessCRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression
Metastatic prostate cancer (PCa) poses a significant therapeutic challenge with high mortality rates. Utilizing CRISPR-Cas9 in vivo, we target five potential tumor suppressor genes (Pten, Trp53, Rb1, Stk11, an...
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Article
Open AccessA mediator of OsbZIP46 deactivation and degradation negatively regulates seed dormancy in rice
Preharvest sprouting (PHS) is a deleterious phenotype that occurs frequently in rice-growing regions where the temperature and precipitation are high. It negatively affects yield, quality, and downstream grain...
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Article
Open AccessFc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma
Multiple myeloma (MM) remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell (CAR-T) therapy. Current targets of CAR-T cells used in MM immunotherapy have limitat...
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Chapter and Conference Paper
Research on Temperature Characteristics of Space Charge Distribution in Epoxy Composites for HVDC GIL
To study the effect of temperature on the space charge characteristics of epoxy composites for HVDC GIL, epoxy/alumina micro-composites (EP-AL) and epoxy/silica micro-composites (EP-SI) were selected for compa...
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Article
Phase reconstitution and reaction performance of oxygen carrier prepared from copper slag
Copper slag contains a large variety of resources that can be used, and is a kind of ‘artificial ore’. This study proposed that the abundant metal oxides in copper slag can be used as oxygen carriers with high...
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Chapter
Coded Aperture Snapshot Spectral Imager
We introduce the motivation and principle of coded optical imaging using the example of snapshot compressive imaging, in particular the coded aperture snapshot spectral imager (CASSI). The key idea is to condu...
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Article
Open AccessLigilactobacillus Salivarius improve body growth and anti-oxidation capacity of broiler chickens via regulation of the microbiota-gut-brain axis
Certain strains of probiotic bacteria can secret functional substances namely digestive enzymes and functional peptides to regulate physiological conditions such as digestion and anti-oxidation, which are ofte...
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Article
Open AccessChronic gastritis may predict risk of cerebral small vessel disease
Chronic gastritis, especially that caused by helicobacter pylori (HP) infection, has been associated with increased risk of ischemic stroke. But the relationship between chronic gastritis and cerebral small ve...
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Article
The impact of students’ cellphone-use and self-control on academic performance in traditional classroom
Cellphone-use in class has many negative effects on students' overall performance. By using a self-developed monitoring-app to record students' cellphone-use in class, this study attempts to explore the relati...
