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Article
A Distributed Regression Analysis Application Package Using SAS
Distributed regression is a privacy-preserving analytical method that performs multiple regression analysis using only summary-level information from participating data partners in multi-center studies. To our...
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Article
Open AccessReflectance confocal microscopy for plaque psoriasis therapeutic follow-up during an anti-interleukin-17A monoclonal antibody: an observational study
Interleukin-17A therapeutic inhibitors are among the most effective treatment methods for moderate-to-severe plaque psoriasis (PP). Reflectance confocal microscopy is a non-invasive imaging technique already d...
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Article
Micro-expression recognition based on contextual transformer networks
Micro-expression is a kind of unintentional facial expression that can reflect the genuine emotion. As a contactless affective computing method, micro-expressions have received attention from psychology and co...
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Article
A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research
Owing to their distinct physical and chemical properties, inorganic nanoparticles (NPs) have shown promising results in preclinical cancer therapy, but designing and engineering them for effective therapeutic ...
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Article
Open AccessChildhood adversity, perceived social support, and depressive symptoms among pre-abortion Chinese women
Unintended (unwanted) pregnancy is a sexual and reproductive health issue with psychosocial consequences for the individual, their family, and society. However, the relationship between social support and rela...
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Article
High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma
Protein phosphatase 1 catalytic subunit gamma (PPP1CC) promotes DNA repair and tumor development and progression, however, its underlying mechanisms remain unclear. This study investigated the molecular mechan...
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Article
Open AccessStratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes
Breast cancer was the most common type of cancer among women worldwide, significantly impacting their quality of life and survival rates. And obesity has been widely accepted as an important risk factor for br...
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Article
Open AccessIn situ observation of mass ejections caused by magnetic reconnections in the ionosphere of Mars
Explosive mass ejections triggered by magnetic activities are common on our Sun and other stars in the Universe. However, there is a lack of evidence for such explosive phenomena in magnetized or partially mag...
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Open AccessAuthor Correction: One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes
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Article
Edible traditional Chinese medicines improve type 2 diabetes by modulating gut microbiotal metabolites
Type 2 diabetes mellitus (T2DM) is a metabolic disorder with intricate pathogenic mechanisms. Despite the availability of various oral medications for controlling the condition, reports of poor glycemic contro...
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Article
Open AccessOne-Tip enables comprehensive proteome coverage in minimal cells and single zygotes
Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investment...
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Article
Open AccessAntidepressant fluoxetine alleviates colitis by resha** intestinal microenvironment
The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear.
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Article
Open AccessExploring Aeromonas dhakensis in Aldabra giant tortoises: a debut report and genetic characterization
Aeromonas dhakensis (A. dhakensis) is becoming an emerging pathogen worldwide, with an increasingly significant role in animals and human health. It is a ubiquitous bacteria found in terrestrial and aquatic milie...
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Article
Open AccessSpatially organized cellular communities form the develo** human heart
The heart, which is the first organ to develop, is highly dependent on its form to function1,2. However, how diverse cardiac cell types spatially coordinate to create the complex morphological structures that are...
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Article
Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning
In vitro systems that accurately model in vivo conditions in the gastrointestinal tract may aid the development of oral drugs with greater bioavailability. Here we show that the interaction profiles between dr...
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Article
Uterine arteries pulsatility index by Doppler ultrasound in the prediction of preeclampsia: an updated systematic review and meta-analysis
Preeclampsia is a common pregnancy complication with serious potential risks for maternal and neonatal health. Early prediction of preeclampsia is crucial for timely prevention, surveillance, and treatment to ...
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Article
Dynamic Responses and Energy Absorption of Mechanical Metamaterials Composed of Buckling Beams
The rich dynamic responses and complex dissipation behaviors of metamaterials with different loading speeds and specific stiffness are investigated. To our knowledge, this work studies systematically for the f...
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Article
Open AccessUltra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here we present the narrow-window data-independent acquisition (nDIA) strategy consisting...
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Article
Open AccessGenome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses
Whole-genome screens using CRISPR technologies are powerful tools to identify novel tumour suppressors as well as factors that impact responses of malignant cells to anti-cancer agents. Applying this methodolo...
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Article
Tumor detection based on deep mutual learning in automated breast ultrasound
Tumor detection in automated breast ultrasound (ABUS) images is critical for computer-aided diagnosis. A single deep learning based network is prone to make overconfident prediction. In this paper, a DML-YOLOX...
