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Article
Open AccessM2 Microglia-Derived Exosomes Protect Against Glutamate-Induced HT22 Cell Injury via Exosomal miR-124-3p
As one of the most serious complications of sepsis, sepsis-associated encephalopathy has not been effectively treated or prevented. Exosomes, as a new therapeutic method, play a protective role in neurodegener...
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Article
Open AccessComparing the performance of machine learning and conventional models for predicting atherosclerotic cardiovascular disease in a general Chinese population
Accurately predicting the risk of atherosclerotic cardiovascular disease (ASCVD) is crucial for implementing individualized prevention strategies and improving patient outcomes. Our objective is to develop mac...
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Article
Open AccessCRISPR/Cas13-assisted hepatitis B virus covalently closed circular DNA detection
The formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver is the main cause of persistent hepatitis B virus (HBV) infection. Here, we established highly sensitive and specif...
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Article
Quantitative benefit and risk assessment of cadmium and nutrient levels in Chinese mitten crab (Eriocheir sinensis)
The use of Chinese mitten crabs for human consumption is controversial due to their uptake of heavy metals, such as cadmium (Cd). We developed a formula for quantification of benefit and risk assessment (hazar...
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Article
Open AccessThe critical role of PPARα in the binary switch between life and death induced by endoplasmic reticulum stress
Endoplasmic reticulum stress (ER stress) just like a double-edged sword depending on different conditions in the development of multiple hepatic diseases. But the molecular mechanisms of functional conversion ...
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Article
Connectionist recommendation in the wild: on the utility and scrutability of neural networks for personalized course guidance
The aggregate behaviors of users can collectively encode deep semantic information about the objects with which they interact. In this paper, we demonstrate novel ways in which the synthesis of these data can ...
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Article
Deposition of fan-shaped ZnMoO4 on ZnCo2O4 nanowire arrays for high electrochemical performance
In this research, fan-shaped ZnMoO4 is deposited on flower-like ZnCo2O4 nanowire arrays by two-step hydrothermal method. ZnCo2O4 nanowire is synthesized first and used as the backbone to support ZnMoO4. The flowe...
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Article
Amyloid-β depresses excitatory cholinergic synaptic transmission in Drosophila
Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to cognitive dysfunctions like Alzheimer’s disease (AD). Although amyloid-β (Aβ) aggregation is a pathological hallmark of AD,...
