Skip to main content

6 Result(s)

within Zhong-jian Wang Remove this filter

and

  1. No Access

    Article

    Dose-individualization Efficiently Maintains Sufficient Exposure to Methotrexate without Additional Toxicity in High-dose Methotrexate Regimens for Pediatric Acute Lymphoblastic Leukemia

    Methotrexate (MTX) can be safely administered to most patients but may cause severe toxicity in others. This study aimed to summarize the characteristics of high-dose methotrexate (HD-MTX) chemotherapy and to ...

    Ya-qing Shen, Zhu-jun Wang, **ao-yan Wu, Kun Li, Zhong-jian Wang… in Current Medical Science (2022)

  2. No Access

    Article

    A New Immunosuppressive Therapy for Very Severe Aplastic Anemia in Children with Autoantibodies

    At present, a number of very severe aplastic anemia (VSAA) patients cannot receive hematopoietic stem cell transplantation (HSCT) or standard immunosuppressive therapy (IST) due to the high cost of therapy, sh...

    Zhong-jian Wang, Hong-bo Chen, Fen Zhou, Hui Yu, **ao-yan Wu… in Current Medical Science (2022)

  3. No Access

    Article

    Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine

    P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are involved in intestinal barrier. Short-chain fatty acids (SCFAs) play important roles in maintaining intestinal barrier. In this study we ex...

    Qiu-shi **e, Jia-xin Zhang, Ming Liu, Pei-hua Liu… in Acta Pharmacologica Sinica (2021)

  4. No Access

    Article

    Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans

    Vonoprazan is characterized as having a long-lasting antisecretory effect on gastric acid. In this study we developed a physiologically based pharmacokinetic (PBPK)-pharmacodynamic (PD) model linking to stomac...

    Wei-min Kong, Bin-bin Sun, Zhong-jian Wang, **ao-ke Zheng… in Acta Pharmacologica Sinica (2020)

  5. Article

    Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp

    HIV infection is often associated with liver failure, which alters the pharmacokinetics of many drugs. In this study we investigated whether acute liver failure (ALF) altered the pharmacokinetics of the first-...

    Fan Wang, Ming-xing Miao, Bin-bin Sun, Zhong-jian Wang… in Acta Pharmacologica Sinica (2017)

    Download PDF (951 KB) View Article

  6. Article

    Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats

    Liver failure is associated with dyshomeostasis of efflux transporters at the blood-brain barrier (BBB), which contributes to hepatic encephalopathy. In this study we examined whether breast cancer resistance ...

    ** Xu, Zhao-li Ling, Ji Zhang, Ying Li, Nan Shu… in Acta Pharmacologica Sinica (2016)

    Download PDF (1796 KB) View Article