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Open AccessAngiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization
The tumor vasculature was different from the normal vasculature in both function and morphology, which caused hypoxia in the tumor microenvironment (TME). Previous anti-angiogenesis therapy had led to a modest...
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Six application scenarios of artificial intelligence in the precise diagnosis and treatment of liver cancer
The establishment of the precision diagnosis and treatment system and the advent of the digital intelligence era have not only deepened people's understanding of liver cancer but also continuously improved the...
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Article
Open AccessPoliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy
Immune checkpoint molecules, also known as cosignaling molecules, are pivotal cell-surface molecules that control immune cell responses by either promoting (costimulatory molecules) or inhibiting (coinhibitory...
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Article
Open AccessIdentification of C-glycosyl flavones by high performance liquid chromatography electrospray ionization mass spectrometry and quantification of five main C-glycosyl flavones in Flickingeria fimbriata
Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine (TCM), however the quality control of it is incomplete. In this work, we aim to identify and quantify the structures of C-glyc...
