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Article
Open AccessCharacterization of the Expressions and m6A Methylation Modification Patterns of mRNAs and lncRNAs in a Spinal Cord Injury Rat Model
Spinal cord injury (SCI) is a serious central nervous system disease with no effective treatment strategy presently due to its complex pathogenic mechanism. N6-methyladenosine (m6A) methylation modification pl...
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Article
Optimizing vancomycin dosing in pediatrics: a machine learning approach to predict trough concentrations in children under four years of age
Vancomycin trough concentration is closely associated with clinical efficacy and toxicity. Predicting vancomycin trough concentrations in pediatric patients is challenging due to significant inter-individual v...
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Article
Open AccessEmpagliflozin in children with glycogen storage disease-associated inflammatory bowel disease: a prospective, single-arm, open-label clinical trial
Glycogen storage disease type Ib (GSD-Ib) is a rare inborn error of glycogen metabolism caused by mutations in SLC37A4. Patients with GSD-Ib are at high risk of develo** inflammatory bowel disease (IBD). We ...
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Chapter and Conference Paper
FDR Cable Defect Detection Method Based on Attenuation Compensation
A cable defect detection method based on attenuation compensation is proposed to address the current issue of frequency domain reflection (FDR) method in detecting cables, where the signal attenuates significa...
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Article
Preparation of N-doped porous biochar with high specific surface area and its efficient adsorption for mercury ion from aqueous solution
Herein, a new type of super active nitrogen-doped biochar sheet (SNBC) was prepared by two-step pyrolysis and KOH chemical activation with melamine and cherry kernel powder as precursors of nitrogen and carbon...
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Article
Evaluation of the effect of a 2D ripple filter on the averaged LET and RBE for proton and carbon ion beams: a Monte Carlo simulation study
The ripple filter (RiFi), one of the passive energy modulators, is commonly used in carbon radiotherapy to enlarge the pristine Bragg peak width and reduce the irradiation time. In this work, the impact of a n...
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Article
Microbial-driven ectopic uranium extraction with net electrical energy production
The extraction of uranium (U) from U-bearing wastewater is of paramount importance for mitigating negative environmental impacts and recovering U resources. Microbial reduction of soluble hexavalent uranium (U...
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Article
Open AccessHematopoietic stem cell transplantation for CYBB heterozygous mutation resulting in very early onset inflammatory bowel disease in children: a case report
Inflammatory bowel disease (IBD) is a heterogeneous group of disorders associated with environmental triggers and dysregulated immune responses resulting in chronic, recurrent intestinal inflammation. Very ear...
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Article
Unraveling the functional characterization of a jasmonate-induced flavonoid biosynthetic CYP45082G24 gene in Carthamus tinctorius
The cytochrome P450 superfamily of monooxygenases plays a major role in the evolution and diversification of plant natural products. The function of cytochrome P450s in physiological adaptability, secondary me...
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Article
Synthesis and characterisation of new-style thin-walled porous light carbon functional materials with residual oxidised coal as the carbon source
A new thin-walled porous light carbon (TPLC) material was prepared innovatively by microwave carbonisation and activation using oxidised coal residues as the carbon source. The main factors affecting the struc...
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Article
Central pattern generator network model for the alternating hind limb gait of rats based on the modified Van der Pol equation
Herein, we employed a central pattern generator (CPG), a spinal cord neural network that regulates lower-limb gait during intra-spinal micro-stimulation (ISMS). Particularly, ISMS was used to determine the spa...
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Article
Defect-adaptive Stem-cell-microcarrier Construct Promotes Tissue Repair in Rabbits with Knee Cartilage Defects
Although various reconstruction techniques are available for cartilage defects, the repair effects and conveniences remain to be further improved due to the limited regenerative capacity of cartilaginous tissu...
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Article
Open AccessNeutrophil extracellular traps induce the bone erosion of gout
To investigate the relationships between monosodium urate (MSU) crystals -induced neutrophil extracellular traps (NETs) and bone erosion in gout.
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Article
Open AccessDrug-induced liver injury following the use of tocilizumab or sarilumab in patients with coronavirus disease 2019
Interleukin-6 (IL-6) blockers including tocilizumab and sarilumab were approved by the U.S. Food and Drug Administration (FDA) in June 2021 for the treatment of patients with moderate to severe COVID-19. The u...
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Article
Open AccessRelapsing subarachnoid hemorrhage as a clinical manifestation in microscopic polyangiitis: a case report and literature review
Microscopic polyangiitis (MPA) is a systemic small-vessel vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA) and predominantly causes kidney and pulmonary injuries. Subarachnoid hemorrhage,...
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Article
Open AccessAttitudes toward posthumous assisted reproduction in China: a multi-dimensional survey
Professional legislation and ethics guidelines for posthumous assisted reproduction (PAR) are lacking in China. This study aims to measure the attitudes of the general public, IVF couples, and assisted reprodu...
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Article
Open AccessElevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice
Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnorm...
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Article
Open AccessDexamethasone Restores the Repressive Effect of Tumor Necrosis Factor-α on Follicular Growth and E2 Secretion During the In Vitro Culture of Preantral Follicles
As a proinflammatory cytokine, tumor necrosis factor-α (TNF-α) is central to the female reproductive tract and affects various phases of follicular development and uterine cycles. High levels of TNF-α play a v...
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Article
Open AccessOxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this ph...
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Article
Correction to: CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic syndrome
The original publication of this paper contains two errors. We apologize for any inconvenience this may have caused.
