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Article
Open AccessCleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability
Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven difficult to elicit. To gain i...
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Chapter and Conference Paper
Efficient Dual-Process Cognitive Recommender Balancing Accuracy and Diversity
In this paper, we propose a dual-process cognitive recommendation system for sequential recommendations. The framework includes an intuitive representation module (System 1) and an inference module (System 2)....
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Article
Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy
Recombinant TRAIL and agonistic antibodies to death receptors (DRs) have been in clinical trial but displayed limited anti-cancer efficacy. Lack of functional DR expression in tumors is a major limiting factor...
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Article
Correction: Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
Nat. Med.; doi:10.1038/nm.4070; corrected online 22 April 2016 In Figure 2a of the version of this article initially published online, one phenyl ring was inadvertently deleted from the chemical structure of c...
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Article
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
ROR-γ antagonists suppress androgen receptor expression and growth of prostate tumors, but not of androgen-responsive healthy tissue, in preclinical models.
