68 Result(s)

Article

Using a smartphone-based self-management platform to study sex differences in Parkinson’s disease: multicenter, cross-sectional pilot study

Patient-reported outcome (PRO) is a distinct and indispensable dimension of clinical characteristics and recent advances have made remote PRO measurement possible. Sex difference in PRO of Parkinson’s disease ...

Zhiheng Xu, Lirong **, Weijie Chen… in BMC Medical Informatics and Decision Making (2024)

Article

Disease progression in proposed brain-first and body-first Parkinson’s disease subtypes

A new Parkinson’s disease (PD) subty** model has been recently proposed based on the initial location of α-synuclein inclusions, which divides PD patients into the brain-first subtype and the body-first subt...

Zhiheng Xu, Tianyu Hu, Chenqin Xu, **aoniu Liang, Shiyu Li… in npj Parkinson's Disease (2024)

Article

PCDHA9 as a candidate gene for amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic factors, we analyzed exome sequences in a large cohort of Chinese ALS patients and found a homozyg...

Jie Zhong, Chaodong Wang, Dan Zhang, **aoli Yao, Quanzhen Zhao… in Nature Communications (2024)

Article

Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum

Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq and spatial transcriptomic analyses of fetal samples from gest...

Fuqiang Yang, Ziqi Zhao, Dan Zhang, Yu **ong, **nran Dong, Yuchen Wang… in Cell Discovery (2024)

Article

Experimental study on the buffering effects of urban trees group in dike-break floods

The process of dike-break flood propagation in typical urban street is highly complex. The presence of buildings and trees groups in urban street profoundly alters the flood dynamics, impacting the drainage ca...

Shuyu Liu, **aolei Zhang, Zhiheng Xu, Jiankun Zhao, Boliang Dong in Scientific Reports (2023)

Article

WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice

Brain size abnormality is correlated with an increased frequency of autism spectrum disorder (ASD) in offspring. Genetic analysis indicates that heterozygous mutations of the WD repeat domain 62 (WDR62) are assoc...

Dan Xu, Yiqiang Zhi, **nyi Liu, Le Guan, Jurui Yu, Dan Zhang… in Neuroscience Bulletin (2023)

Article

Author Correction: Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan… in Cell Research (2023)

Article

A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity

To understand how the nervous system develops from a small pool of progenitors during early embryonic development, it is fundamentally important to identify the diversity of neuronal subtypes, decode the origi...

Mengmeng Ge, Amirhossein Sheikhshahrokh, **ang Shi, Yu-Hong Zhang… in Neuroscience Bulletin (2023)

Article

Plasma GFAP in Parkinson’s disease with cognitive impairment and its potential to predict conversion to dementia

Glial fibrillary acidic protein (GFAP) has been suggested as a biomarker for reactive astrogliosis. We measured the levels of plasma GFAP by Simoa in 60 patients with PD with normal cognition, 63 with mild cog...

Yilin Tang, Linlin Han, Shiyu Li, Tianyu Hu, Zhiheng Xu, Yun Fan… in npj Parkinson's Disease (2023)

Article

Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is one of most common comorbidities in acute respiratory distress syndrome (ARDS). There are few specific studies on the appropriate ventilation strategy for patien...

Xuesong Liu, **ao Liu, Jue Meng, Dongdong Liu, Yongbo Huang, Ling Sang… in Critical Care (2022)

Article

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

The differences in size and function between primate and rodent brains, and the association of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight the importance to study p...

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan… in Cell Research (2022)

Article

Treatment of SARS-CoV-2-induced pneumonia with NAD⁺ and NMN in two mouse models

The global COVID-19 epidemic has spread rapidly around the world and caused the death of more than 5 million people. It is urgent to develop effective strategies to treat COVID-19 patients. Here, we revealed t...

Yisheng Jiang, Yongqiang Deng, Huanhuan Pang, Tiantian Ma, Qing Ye… in Cell Discovery (2022)

Article

Aberrant NAD⁺ metabolism underlies Zika virus–induced microcephaly

Zika virus (ZIKV) infection during pregnancy can cause microcephaly in newborns, yet the underlying mechanisms remain largely unexplored. Here, we reveal extensive and large-scale metabolic reprogramming event...

Huanhuan Pang, Yisheng Jiang, Jie Li, Yushen Wang, Meng Nie, Nan **ao… in Nature Metabolism (2021)

Article

SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development

Mutations of WD40 repeat domain 60 (WDR60) have been identified in short-rib polydactyly syndromes (SRPS I–V), a group of lethal congenital disorders characterized by short ribs, polydactyly, and a range of extra...

Cui Li, Yu Zheng, Yufang Zheng, Zhiheng Xu in Cell Death & Disease (2021)