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Article
Open AccessPerioperative chemotherapy with docetaxel plus oxaliplatin and S-1 (DOS) versus oxaliplatin plus S-1 (SOX) for the treatment of locally advanced gastric or gastro-esophageal junction adenocarcinoma (MATCH): an open-label, randomized, phase 2 clinical trial
It remains unclear whether addition of docetaxel to the combination of a platinum and fluoropyrimidine could provide more clinical benefits than doublet chemotherapies in the perioperative treatment for locall...
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Article
Open AccessA near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator
Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service lifetime. Here, we propose a breeze wake...
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Article
Impacts of land use/cover and slope on the spatial distribution and ecological risk of trace metals in soils affected by smelting emissions
The soil contamination around smelting sites shows high spatial heterogeneity. This study investigated the impacts of distance, land use/cover types, land slopes, wind direction, and soil properties on the dis...
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Article
Open AccessDual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer
To construct and validate a prediction model based on dual-layer detector spectral CT (DLCT) and clinico-radiologic features to predict the microsatellite instability (MSI) status of gastric cancer (GC) and to...
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Article
Effects of Simulated Reclaimed Water on Soil Particle Sizes and Cd Adsorption and Migration in Soils at Smelting Sites
This work studied the vertical migration characteristics of Cd in soil profiles from a zinc smelting site under the influence of simulated reclaimed water containing NaCl and Na2SO4. The isothermal adsorption cur...
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Article
Open AccessNeoadjuvant chemotherapy with modified FOLFOXIRI for locally advanced rectal cancer to transform effectively EMVI and MRF from positive to negative: results of a long-term single center phase 2 clinical trial
Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherap...
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Article
Adsorption of Cd on Soils with Various Particle Sizes from an Abandoned Non-ferrous Smelting Site: Characteristics and Mechanism
Soil particle size could intensively impact the Cd adsorption in soils. The adsorption characteristics of Cd on miscellaneous fill (MF) and weathered slate (WS), collected from a zinc smelting site, were studi...
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Article
The expression and clinical significance of GPR39 in colon cancer
Colorectal cancer is the third most common cancer and requires more prognostic biomarkers for precise treatment. GPR39 is a GPCR which can interact with Zn and modulate the colonocytes’ survival. The clinical ...
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Article
Bifurcation analysis in a diffusion mussel-algae interaction system with delays considering the half-saturation constant
In this paper, the kinetics of a class of delayed reaction-diffusion mussel-algae system under Neumann boundary conditions with the half-saturation constant is studied. The global existence and priori bounds a...
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Article
Open AccessBiweekly oxaliplatin plus S1 for Chinese elderly patients with advanced gastric or gastroesophageal junction cancer as the first-line therapy: a single-arm, phase 2 study
SOX (oxaliplatin and S1, every 3 weeks) is one of the most common first-line chemotherapy for advanced or metastatic G/GEJ (gastric or gastroesophageal junction) cancer in Asia, but it has noticeable hematolog...
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Article
Open AccessAnlotinib in the treatment of advanced hepatocellular carcinoma: an open-label phase II study (ALTER-0802 study)
This study aimed to assess efficacy and safety of anlotinib as a first- or second-line treatment for advanced or metastatic hepatocellular carcinoma (aHCC) and to identify the predictive plasma cytokines on ef...
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Article
Detecting disease-related SNP loci based on GSP
A large number of studies have shown that susceptibility to some diseases may be related to some SNP (Single Nucleotide Polymorphism) loci. Accurate location of disease-related SNP loci can help people underst...
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Article
Open AccessDynamics analysis of a delayed virus model with two different transmission methods and treatments
In this paper, a delayed virus model with two different transmission methods and treatments is investigated. This model is a time-delayed version of the model in (Zhang et al. in Comput. Math. Methods Med. 201...
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Article
Identification and Adjustment of the Pretension Deviation in Cable-Strut Tensile Structures
Construction errors inevitably arise in real cable-strut tensile structures. Nevertheless, construction error analysis and evaluation, as well as methods to identify the source of the errors and proper adjustm...
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Article
Open AccessNab-paclitaxel plus S-1 as first-line followed by S-1 maintenance for advanced pancreatic adenocarcinoma: a single-arm phase II trial
We conducted a single-arm prospective phase II study to determine the efficacy and safety of the first-line treatment of advanced pancreatic cancer with nab-paclitaxel and S-1 followed by S-1 maintenance therapy.
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Article
Open AccessNovel human microbe-disease association prediction using network consistency projection
Accumulating biological and clinical reports have indicated that imbalance of microbial community is closely associated with occurrence and development of various complex human diseases. Identifying potential ...
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Chapter and Conference Paper
MD-MSVMs: A Human Promoter Recognition Method Based on Single Nucleotide Statistics and Multilayer Decision
The prediction and recognition of promoter in human genome play an important role in DNA sequence analysis. Nucleotide content is a multiple utility in bioinformatics details analysis. The single nucleotide s...
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Chapter and Conference Paper
CMFHMDA: Collaborative Matrix Factorization for Human Microbe-Disease Association Prediction
The research on microorganisms indicates that microbes are abundant in human body, which have closely connection with various human noninfectious diseases. The deep research of microbe-disease associations is ...
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Chapter and Conference Paper
Prediction of Lysine Pupylation Sites with Machine Learning Methods
Post translational modification is a crucial type of protein post-translational modification, which is involved in many important cellular processes and serious diseases. In practice, identification of protei...
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Chapter and Conference Paper
DSD-SVMs: Human Promoter Recognition Based on Multiple Deep Divergence Features
Accurate prediction and recognition of promoters remains a challenge in DNA sequence analysis. In this paper, the gene set firstly can be divided into two parts by CpG-island analysis. Then, in each part, a s...
