18 Result(s)
within
ZhiQing Pang
English
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Article
Effect of EGF1 peptides in directing nanoparticles to thrombi
In order to examine the effect of EGF1 peptides in directing nanoparticles to thrombi, the synthesized EGF1 peptide was conjugated to poly (ethyleneglycol)-poly (lactide) (PEG-PLA) nanoparticles (NP) to form E...
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Determination of Fulvestrant in Rat Plasma by LC–MS–MS: Application to a Pharmacokinetic Study
A reversed-phase liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) method was developed and validated for the determination of fulvestrant in rat plasma. Sample preparation involved a liquid...
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Article
Self-Assembled Polymersomes Conjugated with Lactoferrin as Novel Drug Carrier for Brain Delivery
To develop a novel brain drug delivery system based on self-assembled poly(ethyleneglycol)-poly (D,L-lactic-co-glycolic acid) (PEG-PLGA) polymersomes conjugated with lactoferrin (Lf-POS). The brain delivery pr...
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Article
Anti-glioma effect and safety of docetaxel-loaded nanoemulsion
Docetaxel, an inhibitor of microtubule depolymerization, has been used for many malignancies. Due to its toxicity and the non-selective distribution of its commercial formulation, Taxotere®, new formulations w...
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Identification of peptide sequences that target to the brain using in vivo phage display
Phage display technology could provide a rapid means for the discovery of novel peptides. To find peptide ligands specific for the brain vascular receptors, we performed a modified phage display method. Phages...
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Brain Delivery of NAP with PEG-PLGA Nanoparticles Modified with Phage Display Peptides
A phage-displayed peptide TGN was used as a targeting motif to help the delivery of NAP-loaded nanoparticles across the blood–brain barrier (BBB), which sets an obstacle for brain delivery of NAP in vivo.
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Article
Open AccessLigand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization
Nanoparticles (NPs) were widely used in drugs/probes delivery for improved disease diagnosis and/or treatment. Targeted delivery to cancer cells is a highly attractive application of NPs. However, few studies ...
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Article
Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System
Major central nervous system (CNS) disorders, including brain tumors, Alzheimer’s disease, Parkinson’s disease, and stroke, are significant threats to human health. Although impressive advances in the treatmen...
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Article
Correction: Corrigendum: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization
Nanoparticles (NPs) were widely used in drugs/probes delivery for improved disease diagnosis and/or treatment. Targeted delivery to cancer cells is a highly attractive application of NPs. However, few studies ...
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Article
Quantification of Dopamine in Brain Microdialysates with High-Performance Liquid Chromatography-Tandem Mass Spectrometry
The dopamine level in the brain and the mesolimbick dopaminergic system are responsible for nicotine addiction. In the present study, extracellular dopamine in nucleus accumbens was collected by a brain microd...
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Open AccessCelecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice
Barriers presented by the tumor microenvironment including the abnormal tumor vasculature and interstitial matrix invariably lead to heterogeneous distribution of nanotherapeutics. Inspired by the close associ...
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Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis
The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-tar...
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Tumor Microenvironment and Intracellular Signal-Activated Nanocomposites for Anticancer Drug Delivery
The use of nanomaterials for drug delivery and cancer therapy has well established itself over the past decades. Compared with free chemotherapeutics, nanoparticle drug delivery systems achieve better performa...
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Open AccessDual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer
Due to the presence of the blood–brain barrier (BBB), the delivery of general drugs into the brain tissue remains to be a tricky problem. For patients with brain metastases from breast cancer, drug delivery sy...
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Open AccessTargeted neutrophil-mimetic liposomes promote cardiac repair by adsorbing proinflammatory cytokines and regulating the immune microenvironment
Acute myocardial infarction (MI) induces a sterile inflammatory response that may result in poor cardiac remodeling and dysfunction. Despite the progress in anti-cytokine biologics, anti-inflammation therapy o...
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Versatile nanocomposite augments high-intensity focused ultrasound for high-efficacy sonodynamic therapy of glioma
High-intensity focused ultrasound (HIFU), with inherent advantages of improved ultrasonic depth and low off-target damage, holds the promising capability for glioma treatment, but the relatively long therapeut...
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Open AccessTargeted delivery and ROS-responsive release of Resolvin D1 by platelet chimeric liposome ameliorates myocardial ischemia–reperfusion injury
Resolvin D1 (RvD1) has been shown to provide effective protection against ischemia–reperfusion injury in multiple vital organs such as the heart, brain, kidney. However, the clinical translational potential of...
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Article
Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction
Activation of the local renin–angiotensin system (RAS) promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction (AMI). As an anti-RAS drug, the effect of Valsartan in the early...
