-
Article
Potential protective effects of sodium butyrate on glycinin-induced oxidative stress, inflammatory response, and growth inhibition in Cyprinus carpio
Investigated mitigating effects of sodium butyrate (SB) on the inflammatory response, oxidative stress, and growth inhibition of common carp (Cyprinus carpio) (2.94 ± 0.2 g) are caused by glycinin. Six isonitroge...
-
Article
Open AccessTrispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections
Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a tr...
-
Article
Conformational Behavior of Single Circular Semiflexible Polyelectrolyte in the Presence of Multivalent Counterions
Langevin dynamics simulations are employed to explore the effects of chain stiffness and electrostatic interaction (EI) on the conformational behavior of a circular semiflexible polyelectrolyte (CSPE) in prese...
-
Article
Role of pyroglutamic acid in cumulus cells of women with polycystic ovary syndrome
Polycystic ovary syndrome is a complex heterogeneous endocrine disorder associated with established metabolic abnormalities and is a common cause of infertility in females. Glutathione metabolism in the cumulu...
-
Article
Microstructure and mechanical properties of as-cast (CuNi)100−xCox medium-entropy alloys
Microstructure and mechanical properties of non-equiatomic (CuNi)100−xCox (x=15, 20, 25 and 30, at.%) medium-entropy alloys (MEAs) prepared by vacuum arc-melting were investigated. Results show that all the as-ca...
-
Article
Open AccessLearning to predict in-hospital mortality risk in the intensive care unit with attention-based temporal convolution network
Dynamic prediction of patient mortality risk in the ICU with time series data is limited due to high dimensionality, uncertainty in sampling intervals, and other issues. A new deep learning method, temporal co...
-
Article
Publisher Correction: A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
-
Article
A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
Effective antitumour immunity depends on the orchestration of potent T cell responses against malignancies1. Regression of human cancers has been induced by immune checkpoint inhibitors, T cell engagers or chimer...
-
Article
Atomic-scale characterization of multiple precipitating species in a precipitation-hardened martensitic stainless steel
Multiple precipitating species in a 2.2 GPa grade precipitation-hardened martensitic stainless steel with balanced ductility were characterized at atomic scale by atom probe tomography. The results indicated t...
-
Article
Long-term Therapeutic Outcome and Prognostic Factors of Patients with Nasopharyngeal Carcinoma Receiving Intensity-modulated Radiotherapy: An Analysis of 608 Patients from Low-endemic Regions of China
To evaluate the long-term outcome and prognostic factors of patients with nasopharyngeal carcinoma (NPC) from low-endemic regions of China who received definitive intensity-modulated radiation therapy (IMRT).
-
Article
Carbide dissolution and austenite grain growth behavior of a new ultrahigh-strength stainless steel
The isothermal grain growth behavior for a new ultrahigh-strength stainless steel (UHSSS) is investigated in temperature range from 900 to 1150 °C and holding time range from 0 to 20 min. In the temperature ra...
-
Article
Influence of CyberKnife Prescription Isodose Line on the Discrepancy of Dose Results Calculated by the Ray Tracing and Monte Carlo Algorithms for Head and Lung Plans: A Phantom Study
Incorporation of the Monte Carlo (MC) algorithm in optimizing CyberKnife (CK) plans is cumbersome, and early models unconfgured MC calculations, therefore, this study investigated algorithm-based dose calculat...
-
Article
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Despite the significant therapeutic advances provided by immune-checkpoint blockade and chimeric antigen receptor T cell treatments, many malignancies remain unresponsive to immunotherapy. Bispecific antibodie...
-
Article
Over-the-scope-clip applications for perforated peptic ulcer
To investigate the effectiveness of over-the-scope-clip (OTSC)-based endoscopic closure in patients with perforated peptic ulcer (PPU).
-
Article
Open AccessEstimating intrafraction tumor motion during fiducial-based liver stereotactic radiotherapy via an iterative closest point (ICP) algorithm
Tumor motion may compromise the accuracy of liver stereotactic radiotherapy. In order to carry out a precise planning, estimating liver tumor motion during radiotherapy has received a lot of attention. Previou...
-
Article
Increased TRPM4 Activity in Cerebral Artery Myocytes Contributes to Cerebral Blood Flow Reduction After Subarachnoid Hemorrhage in Rats
Cerebral blood flow (CBF) reduction underlies unfavorable outcomes after subarachnoid hemorrhage (SAH). Transient receptor potential melastatin-4 (TRPM4) has a pivotal role in cerebral artery myogenic tone mai...
-
Chapter
In Vitro Maturation of Human Oocytes
There is a growing interest in natural cycle in vitro fertilization (IVF) and in vitro maturation (IVM) treatment. Recovery of immature oocytes followed by IVM is a potentially useful treatment for women with ...
-
Article
Balloon-assisted ultrasonic localization: a novel technique for direct percutaneous endoscopic jejunostomy
Direct percutaneous endoscopic jejunostomy (DPEJ) is a useful method for the establishment of enteral nutrition (EN) pathway. However, the identification of stomal puncture points for DPEJ is difficult. Here w...
-
Article
A pathway for biological methane production using bacterial iron-only nitrogenase
Methane (CH4) is a potent greenhouse gas that is released from fossil fuels and is also produced by microbial activity, with at least one billion tonnes of CH4 being formed and consumed by microorganisms in a sin...
-
Article
Open AccessMortality in Children with Severe Hand, Foot and Mouth Disease in Guangxi, China
To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died.
