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Article
Development characteristics and failure modes of reactivated ancient landslides in the Sichuan–Tibet transportation corridor, China
The risk of reactivated ancient landslides in the Sichuan–Tibet transportation corridor in China is significantly increasing, primarily driven by the intensification of engineering activities and the increased...
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Article
Open AccessHSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma
Identification of promising targeted antigens that exhibited cancer-specific expression is a crucial step in the development of novel antibody-targeted therapies. We here aimed to investigate the anti-tumor ac...
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Article
Open AccessThe complete mitochondrial genome of Eulaelaps huzhuensis (Mesostigmata: Haemogamasidae)
Some mites of the family Haemogamasidae can transmit a variety of zoonotic diseases and have important public health and safety implications. Currently, however, little attention has been paid to molecular dat...
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Article
Field investigations and numerical modeling of a giant landslide in the region of Eastern Himalayan Syntaxis: Jiaobunong landslide
Eastern Himalayan Syntaxis (EHS) is a tectonically active region that undergoes continuous geomorphic changes. Large landslides are predominant in this region. A giant landslide called Jiaobunong landslide on ...
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Article
Open AccessMYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling
The fatality rate of non-small cell lung cancer (NSCLC) has been high due to the existence of cancer stem cells (CSCs). Non-muscle myosin heavy chain 9 (MYH9) can promote the progression of various tumors, but...
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Article
Open AccessAlpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway
Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai...
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Article
Open AccessEnolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis
Recent studies have demonstrated that gastric cancer stem cells (CSCs) are a rare sub-group of gastric cancer (GC) cells and have an important role in promoting the tumor growth and progression of GC. In the p...
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Article
Microstructural evolution and mechanical properties of h-BN composite ceramics with Y2O3–AlN addition by liquid-phase sintering
Hexagonal boron nitride (h-BN) composite ceramics were prepared by hot pressing with the addition of Y2O3 and AlN. The effects of different Y2O3–AlN contents on microstructural evolution, mechanical properties an...
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Article
Mechanical properties and in situ fracture behavior of SiO2f/phosphate geopolymer composites
Geopolymers, such as phosphate-based geopolymer, are promising materials that have drawn extensive attentions as wave-transparent candidates with low dielectric loss factor. In this paper, multilayer SiO2 fibers ...
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Article
Open AccessMethodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?
Methodological quality (risk of bias) assessment is an important step before study initiation usage. Therefore, accurately judging study type is the first priority, and the choosing proper tool is also importa...
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Article
SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson’s disease in Chinese population
Recently, rs2421947 in DNM3 (dynamin 3) was reported as a genetic modifier of age at onset (AAO) of LRRK2 G2019S-related Parkinson’s disease (PD) in a genome-wide association study in Arab-Berber population. Rs35...
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Article
A 2-Stage Strategy for Non-Stationary Signal Prediction and Recovery Using Iterative Filtering and Neural Network
Predicting the future information and recovering the missing data for time series are two vital tasks faced in various application fields. They are often subjected to big challenges, especially when the signal...
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Article
Species abundance distribution and ecological niches of chigger mites on small mammals in Yunnan province, southwest China
The ecological niches and species abundance distributions of chigger mites were studied on small mammal hosts captured from 34 sites in Yunnan Province of southwest China between 2001 and 2015. Levins’ niche b...
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Article
Predicting landslide scenes under potential earthquake scenarios in the **anshuihe fault zone, Southwest China
Earthquake-induced landslides can seriously aggravate the earthquake’s destructive consequences and have caused widespread concern in recent decades. The **anshuihe fault is a large active left-lateral strike-...
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Article
Open AccessGenetic analysis of the TMEM230 gene in Chinese Han patients with Parkinson’s disease
TMEM230 mutations have been recently reported to cause autosomal dominant Parkinson’s disease (PD). However, there are limited studies from different ethnic populations to support the rol...
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Article
Landslide susceptibility map** using an integrated model of information value method and logistic regression in the Bailongjiang watershed, Gansu Province, China
Bailongjiang watershed in southern Gansu province, China, is one of the most landslide-prone regions in China, characterized by very high frequency of landslide occurrence. In order to predict the landslide oc...
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Article
Urgent landslide susceptibility assessment in the 2013 Lushan earthquake-impacted area, Sichuan Province, China
The Lushan earthquake with magnitude M s 7.0 (M w 6.6, USGS) in Sichuan Province, China, triggered a large number of landslides, which seriously aggravated the earthquake’s destruc...
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Article
Post-earthquake rainfall-triggered slope stability analysis in the Lushan area
The “4.20” Lushan earthquake in Sichuan province, China has induced a large amount of geological hazards and produced abundant loose materials which are prone to post-earthquake rainfall-triggered landslides. ...
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Article
Nod-Like Receptor Protein 1 Inflammasome Mediates Neuron Injury under High Glucose
Diabetic encephalopathy is one of the most common complications of diabetes. Inflammatory events during diabetes may be an important mechanism of diabetic encephalopathy. Inflammasome is a multiprotein complex...
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Article
miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells
Macrophage apoptosis is a prominent feature of advanced atherosclerotic plaques. Here, we examined the hypothesis that the apoptotic machinery is regulated by microRNA-155 (miR-155). Constitutive expression of...
