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Article
Ubiquitin-specific protease 5 promotes bladder cancer progression through stabilizing Twist1
Aberrant activation of the epithelial-mesenchymal transition (EMT) pathway drives the development of solid tumors, which is precisely regulated by core EMT-related transcription factors, including Twist1. Howe...
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Article
Fatty acid metabolism-related molecular subtypes and a novel model for predicting prognosis in bladder cancer patients
This study aims to develop fatty acid metabolism-related molecular subtypes and construct a fatty acid metabolism-related novel model for bladder cancer (BCa) by bioinformatic profiling. Genome RNA-seq express...
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Article
Open AccessND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid metabolism. However, the function of ND630 in prostate cancer remains unknown. KIF18B,...
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Article
A novel CD8+ T cell-related gene signature for predicting the prognosis and immunotherapy efficacy in bladder cancer
To identify CD8+ T cell-related molecular clusters and establish a novel gene signature for predicting the prognosis and efficacy of immunotherapy in bladder cancer (BCa).
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Article
Exosomal MiR-381 from M2-polarized macrophages attenuates urethral fibroblasts activation through YAP/GLS1-regulated glutaminolysis
Post-traumatic urethral stricture is a clinical challenge for both patients and clinicians. Targeting glutamine metabolism to suppress excessive activation of urethral fibroblasts (UFBs) is assumed to be a pot...
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Article
Low TLR and PSMA-TV predict biochemical response to abiraterone acetate in metastatic prostate cancer patients develo** castration resistance after chemohormonal therapy at hormone-sensitive stage
To explore whether 68Ga-PSMA-11 PET/CT-derived parameters could predict biochemical response to abiraterone acetate (AA) treatment and prognosis in metastatic prostate cancer patients develo** castration resist...
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Article
Risk factors for lymphorrhea and lymphocele after radical prostatectomy: a retrospective case–control study
To investigate the risk factors for postoperative lymphorrhea or/and lymphocele (PLL) in patients undergoing radical prostatectomy (RP).
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Article
Head-to-head comparisons of [68Ga]Ga-PSMA-11 PET/CT, multiparametric MRI, and prostate-specific antigen for the evaluation of therapeutic responses to neoadjuvant chemohormonal therapy in high-risk non-metastatic prostate cancer patients: a prospective study
The optimal tool to evaluate the tumour therapeutic responses to neoadjuvant chemohormonal therapy (NCHT) in patients with high-risk non-metastatic prostate cancer (PCa) remains uncertain. We compared the role...
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Article
Open AccessARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes
This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, and to discern their biological functions.
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Article
Open AccessSonographic and pathological features of metaplastic squamous cell carcinoma of the breast: a case series
The aim of this study was to evaluate the sonographic features and to compare the sonographic findings with the pathologic features.
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Article
Open AccessKinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells
Expression of kinesin family member 18B (KIF18B), an ATPase with key roles in cell division, is deregulated in many cancers, but its involvement in prostate cancer (PCa) is unclear. Here, we investigated the e...
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Article
Open AccessTumor volume: a new prognostic factor of oncological outcome of localized clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor...
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Article
Open AccessDevelopment and validation of a molecular prognostic index of bladder cancer based on immunogenomic landscape analysis
Bladder cancer (BCa) is one of the important tumors that have been proven to be treatable with immunotherapy. This study aims to identify and validate a molecular prognostic index of BCa based on immunogenomic...
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Article
Open AccessIdentification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data
Prostate cancer (PCa) remains the second leading cause of deaths due to cancer in the United States in men. The aim of this study was to perform an integrative epigenetic analysis of prostate adenocarcinoma to...
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Article
Can Prostate Imaging Reporting and Data System Version 2 reduce unnecessary prostate biopsies in men with PSA levels of 4–10 ng/ml?
To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4–10 ng/ml.
