80 Result(s)

Article

Electrophysiological characteristics and catheter ablation of ventricular arrhythmias arising from the superior septal left ventricle

Electrophysiological characteristics and radiofrequency catheter ablation (RFCA) of premature ventricular contractions (PVCs) originating from the superior septal left ventricle (SSLV) have not yet been fully ...

Qifang Liu, Ye Tian, Zhi Jiang, Longhai Tian, **g Huang… in BMC Cardiovascular Disorders (2024)

Article

The potential association between metabolic disorders and pulmonary tuberculosis: a Mendelian randomization study

Metabolic disorders (MetDs) have been demonstrated to be closely linked to numerous diseases. However, the precise association between MetDs and pulmonary tuberculosis (PTB) remains poorly understood.

Zhi-xiang Du, Yun-yao Ren, Jia-luo Wang… in European Journal of Medical Research (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

METTL14 downregulation drives S100A4⁺ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Without intervention, a considerable proportion of patients with metabolism‐associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism‐associated steatohepatitis (MASH), liver fib...

Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li… in Signal Transduction and Targeted Therapy (2024)

Article

Establishment of stellate ganglion block in mice

There have been no reports on the successful implementation of stellate ganglion block (SGB) in mice.

Qirui Duan, Ying Zhou, Juan Zhi, Quanle Liu, ** Xu… in European Journal of Medical Research (2024)

Article

Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function

GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on the unique interaction between the tumor and the tumor microenvironment (TME). However, the cu...

Si-yu Wang, Yu-xin Wang, Ao Shen, … in European Journal of Medical Research (2024)

Article

Triglyceride glucose-body mass index as a novel predictor of slow coronary flow phenomenon in patients with ischemia and nonobstructive coronary arteries (INOCA)

The triglyceride glucose-body mass index (TyG-BMI index) has been suggested as a novel predictor of insulin resistance. However, its predictive value for slow coronary flow phenomenon (SCFP) in patients with i...

Zhi-peng Li, Juan Chen, Qi **n, **ao-yang Pei, Hong-li Wu… in BMC Cardiovascular Disorders (2024)

Article

Circulating secretoneurin level reflects angiographic coronary collateralization in stable angina patients with chronic total occlusion

To investigate the association between circulating secretoneurin (SN) and angiographic coronary collateralization in stable angina patients with chronic coronary total occlusion (CTO).

Zhi Ming Wu, Ke Huang, Yang Dai, Shuai Chen, **ao Qun Wang… in BMC Cardiovascular Disorders (2024)

Article

Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

Meng-Yao Wang, Bin Qi, Fang Wang, Zhi-Rui Lin, Ming-Yi Li, Wen-**g Yin… in Oncogenesis (2023)

Article

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy

BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although ...

Zhi-Qiang Wang, Zhao-Cong Zhang, Yu-Yang Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study

Hepatic arterial infusion chemotherapy (HAIC) using a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown promise for hepatocellular carcinoma (HCC) patients classified under Barcelona ...

Tian-Qi Zhang, Zhi-Jun Geng, Meng-Xuan Zuo… in Signal Transduction and Targeted Therapy (2023)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts

Diabetes is associated with myocardial fibrosis, while the underlying mechanisms remain elusive. The aim of this study is to investigate the underlying role of calcineurin/nuclear factor of activated T cell 3 ...

Lei Zhang, Huan-Huan Liu, Fan Yang, Zhi-Yuan Zhang, Ying Wu… in BMC Cardiovascular Disorders (2023)

Article

Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells

Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various liver diseases. However, neither LSEC-specific hallmark gen...

Zhi-Wen Li, Bai Ruan, Pei-Jun Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy

**ao-mei Yang, Xuan-dong Lin, Wei Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Safety and efficacy of enterprise stenting for symptomatic atherosclerotic severe posterior circulation stenosis

To investigate the safety and efficacy of Enterprise stent angioplasty and risk factors for the prognoses in treating symptomatic severe posterior circulation atherosclerotic stenosis (SSPCAS).

Zhi-Long Zhou, Tian-**ao Li, Liang-Fu Zhu… in European Journal of Medical Research (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Comparisons of perioperative and long-term outcomes of laparoscopic versus open gastrectomy for advanced gastric cancer after neoadjuvant therapy: an updated pooled analysis of eighteen studies

Outcomes of laparoscopic surgery in advanced gastric cancer patients who received neoadjuvant therapy represent a controversial issue. We performed an updated meta-analysis to evaluate the perioperative and lo...

Hua-Yang Pang, **u-Feng Chen, Li-Hui Chen… in European Journal of Medical Research (2023)

Article

Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1

Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei… in Signal Transduction and Targeted Therapy (2023)

Article

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature senescen...

Lei Chen, Wen**g Zhang, Dan Chen, Quan Yang… in Signal Transduction and Targeted Therapy (2023)