28 Result(s)

Article

Low-dose corticosteroid combined with immunoglobulin reverses deterioration in severe cases with COVID-19

Zhi-Guo Zhou, Di-Xuan Jiang, Shu-Min **e… in Signal Transduction and Targeted Therapy (2020)

Article

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme ...

Ke Wang, Wei Chen, Zheng Zhang, Yongqiang Deng… in Signal Transduction and Targeted Therapy (2020)

Article

UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development

Genomic sequencing analysis of tumors provides potential molecular therapeutic targets for precision medicine. However, identifying a key driver gene or mutation that can be used for hepatocellular carcinoma (...

Ren-Yu Zhang, Ze-Kun Liu, Ding Wei, Yu-Le Yong… in Signal Transduction and Targeted Therapy (2021)

Article

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus with high fatality and an expanding endemic. Currently, effective anti-SFTSV intervention remains unavailable. F...

Hao Li, **a-Ming Jiang, Ning Cui, Chun Yuan… in Signal Transduction and Targeted Therapy (2021)

Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

Huijie Bian, Zhao-Hui Zheng, Ding Wei… in Signal Transduction and Targeted Therapy (2021)

Article

Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation

Lei Fang, Tu-Shuai Li, **g-Zi Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders. Trefoil factor 3 ...

Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng… in Signal Transduction and Targeted Therapy (2021)

Article

RHBDF1 promotes AP-1-activated endothelial–mesenchymal transition in tumor fibrotic stroma formation

Shan Gao, Li-Song Zhang, Lei Wang, Nan-Nan **ao… in Signal Transduction and Targeted Therapy (2021)

Article

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth investigation on COVID-19 pat...

Jiejie Geng, Liang Chen, Yufeng Yuan, Ke Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to m...

Yan Yu, **ao-Dan Peng, **ao-Jun Qian… in Signal Transduction and Targeted Therapy (2021)

Article

Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence

Patients with hepatocellular carcinoma (HCC) have poor long-term survival following curative resection because of the high rate of tumor early recurrence. Little is known about the trajectory of genomic evolut...

Shao-Lai Zhou, Zheng-Jun Zhou, Cheng-Li Song… in Signal Transduction and Targeted Therapy (2022)

Article

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific ...

**u-**u Liu, **ng-Hui Chen, Zhi-Wei Zheng… in Signal Transduction and Targeted Therapy (2022)

Article

CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis

COVID‐19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for...

Jiao Wu, Liang Chen, Chuan Qin, Fei Huo… in Signal Transduction and Targeted Therapy (2022)

Article

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial

An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...

Nawal Al Kaabi, Yun Kai Yang, Yu Liang, Ke Xu… in Signal Transduction and Targeted Therapy (2023)

Article

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vect...

Zhi-Guo Lu, Jie Shen, Jun Yang, **g-Wen Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Immunological and metabolic characteristics of the Omicron variants infection

The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characte...

Jiejie Geng, Xu Yang, Kun Wang, Ke Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to rec...

Huijie Bian, Liang Chen, Zhao-Hui Zheng… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature senescen...

Lei Chen, Wen**g Zhang, Dan Chen, Quan Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1

Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei… in Signal Transduction and Targeted Therapy (2023)