768 Result(s)
within
Biomedicine
Zhi-**a Yang
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Article
Behavioral evidence for the role of noradrenaline in putative anxiolytic and sedative effects of benzodiazepines
The effects of clonidine on the antianxiety and sedation of benzodiazepines (BZD) were assessed respectively in rats trained in a two-lever diazepam cue discrimination procedure and in single-lever fixed-ratio...
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Article
The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo
The p21 gene encodes a cyclin–dependent kinase inhibitor that affects cell–cycle progression, but the potential of this gene product to serve as a tumour suppressor in vivo has not been established. In this repor...
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Protocol
Methods for Liposome-Mediated Gene Transfer to Tumor Cells In Vivo
Despite considerable progress in the understanding of the molecular basis of cancer, many malignancies remain resistant to traditional forms of treatment. Certain cancers, such as melanoma or renal cell carcin...
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Protocol
Methods for Liposome-Mediated Gene Transfer to the Arterial Wall
Cationic liposomes are preparations of positively charged lipids used for transfection of mammalian cells in vitro and in vivo. Although viruses efficiently infect mammalian cells, the potential risks of viral...
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Article
Inhcer of β-Interferon
Balloon injury of the arterial wall induces increased vascular smooth cell proliferation, enhanced elastic recoil, and abnormalities in thrombosis, each of which contribute to regrowth of intima and the lesion...
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Article
Sensitivity of Ca2+ Transport of Mitochondria to Reactive Oxygen Species
The relationship between Ca2+ transport and energy transduction of myocardial mitochondria in the presence of reactive oxygen species was investigated. Following treatment with oxygen free radicals [superoxide(O ...
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Article
Immunization for Ebola virus infection
Infection by Ebola virus causes rapidly progressive, often fatal, symptoms of fever, hemorrhage and hypotension. Previous attempts to elicit protective immunity for this disease have not met with success. We r...
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Article
The APC I1307K allele and breast cancer risk
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Article
Requirements for Enhanced Transgene Expression by Untranslated Sequences from the Human Cytomegalovirus Immediate-Early Gene
The cytomegalovirus immediate early (CMV IE) promoter has been widely used for heterologous expression. Further enhancements of gene expression from this potent promoter may allow for the development of improv...
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Article
Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury
Here we defined the main viral determinant of Ebola virus pathogenicity; synthesis of the virion glycoprotein (GP) of Ebola virus Zaire induced cytotoxic effects in human endothelial cells in vitro and in vivo. T...
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Article
SM22α Promoter Targets Gene Expression to Vascular Smooth Muscle Cells In Vitro and In Vivo
Gene transfer into vascular smooth muscle cells (vsmcs) holds promise for studying the pathogenesis of arterial disorders. However, a potential limitation of vectors with heterologous promoters is organ toxici...
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Article
Prospective study of serum retinol, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China
Objective: This study examined the relationship between pretrial serum concentrations of retinol, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin and the subsequent risk of develo** esophageal squamous cell...
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Article
A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications
Spermatogenesis is an essential stage in the human reproductive process. In a previously study aiming to determine which genes might be involved in spermatogenesis, we compared the gene expression profiles of ...
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Article
Molecular Phylogeny of the Genus Paramesotriton (Caudata: Salamandridae)
To elucidate the phylogeny of the genus Paramesotriton (Caudata: Salamandridae), we investigated three mitochondrial DNA gene fragments (1207 bp in total) of cytochrome b, ND2, and ND4 for its six recognized spec...
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Article
Peroxisome proliferator-activated receptor γ ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines
To study the effect of peroxisome proliferator-actived receptor γ (PPARγ) ligands on cell proliferation and apoptosis in human renal carcinoma cell lines.
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Article
Study on the neurotoxic effects of low-level lead exposure in rats
Objective: To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and on N-methyl-D-aspartate (NMDA) receptor mRNA expression in the hippocampu...
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Article
Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis
To explore the relationship between differential leucocyte count and coronary atherosclerosis.
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Article
Identification of human dopamine D1-like receptor agonist using a cell-based functional assay
To establish a cell-based assay to screen human dopamine D1 and D5 receptor agonists against compounds from a natural product compound library.
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Article
Treatment and follow-up of children with transient congenital hypothyroidism
Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH). Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-...
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Article
Distributive characteristics of Ser49Gly and Gly389Arg genetic polymorphisms of β1-adrenoceptor in Chinese Han and Dai populations
Genetic polymorphisms causing Ser49Gly and Gly389Arg mutants of β1- adrenoceptor may result in significant changes in the function of this receptor. The aim of the present study was to investigate the frequencies...
