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Article
Hybrid PdAg alloy-Au nanorods: Controlled growth, optical properties and electrochemical catalysis
Controllable growth of high-quality hybrid nanostructures is highly desirable for the fabrication of hierarchical, complex and multifunctional devices. Here, PdAg alloys have been controllably grown at differe...
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Article
Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a l...
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Article
Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2
Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell a...
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Article
Nitrogen-doped 3D hierarchical ordered mesoporous carbon supported palladium electrocatalyst for the simultaneous detection of ascorbic acid, dopamine, and glucose
In the present work, nitrogen-doped three-dimensional (3D) hierarchical ordered mesoporous carbon supported palladium (Pd 20 wt%/N-3D) electrocatalyst was successfully synthesized with the nanocasting method. ...
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Article
Open AccessMutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer
Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell-extrinsic role of KRAS, where K...
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Article
Open AccessSecretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species accumulation
Adverse myocardial remodeling, manifesting pathologically as myocardial hypertrophy and fibrosis, often follows myocardial infarction (MI) and results in cardiac dysfunction. In this study, an obvious epicardi...
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Article
Three-year outcomes of transanal total mesorectal excision versus standard laparoscopic total mesorectal excision for mid and low rectal cancer
Since transanal total mesorectal excision (taTME) was introduced, it has become an important topic in rectal cancer treatment. Many previous studies reported positive relevant short-term results, histopatholog...
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Article
Open AccessProtection of zero-valent iron nanoparticles against sepsis and septic heart failure
Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechan...
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Article
Open AccessPredicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers
Recurrence represents a well-known poor prognostic factor for colorectal cancer (CRC) patients. This study aimed to establish an effective prognostic prediction model based on noninvasive circulating tumor DNA...
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Article
Realizing a “solid to solid” process via in situ cathode electrolyte interface (CEI) by solvent-in-salt electrolyte for Li-S batteries
Lithium-sulfur batteries (LSBs) are regarded as the most promising next-generation energy system due to their high theoretical energy density. However, LSBs suffer the “shuttle effect” if undergoing the solid-...
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Article
GAS6/Axl is associated with AMPK activation and attenuates H2O2-induced oxidative stress
Oxidative stress plays a key part in cardiovascular event. Growth arrest-specific gene 6 (GAS6) is a vitamin K-dependent ligand which has been shown to exert important effects in heart. The effects of GAS6 wer...
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Article
Open AccessA non-Newtonian fluid quasi-solid electrolyte designed for long life and high safety Li-O2 batteries
The Li dendrite growth and the liquid electrolyte volatilization under semi-open architecture are intrinsic issues for Li-O2 battery. In this work, we propose a non-Newtonian fluid quasi-solid electrolyte (NNFQSE...
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Article
Open AccessMutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death
Mutant KRAS (KRASMUT) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from KRASMUT ...
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Article
Mitochondrial DNA copy number plays opposing roles in T-lymphocyte infiltration of colorectal cancer based on mismatch repair status: new directions for immunotherapy?
Researchers have previously reported that mitochondrial DNA copy number (mtDNA-CN) can play different roles in microsatellite instable/mismatch repair-deficient (MSI/dMMR) and microsatellite stable/mismatch re...
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Article
Open AccessPeroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a ...
