35 Result(s)

Article

N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1

Refractoriness to surgical resection and chemotherapy makes intrahepatic cholangiocarcinoma (ICC) a fatal cancer of the digestive system with high mortality and poor prognosis. Important function invests circR...

**g Li, **aohong Xu, Kaihao Xu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Roles of exosomes in immunotherapy for solid cancers

Although immunotherapy has made breakthrough progress, its efficacy in solid tumours remains unsatisfactory. Exosomes are the main type of extracellular vesicles that can deliver various intracellular molecule...

Cong Lyu, Haifeng Sun, Zhenqiang Sun, Yang Liu, Qiming Wang in Cell Death & Disease (2024)

Article

Breakthrough of solid tumor treatment: CAR-NK immunotherapy

As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. ...

Wenkang Wang, Yang Liu, Zhen He, Lifeng Li, Senbo Liu… in Cell Death Discovery (2024)

Article

Extracellular vesicles remodel tumor environment for cancer immunotherapy

Tumor immunotherapy has transformed neoplastic disease management, yet low response rates and immune complications persist as major challenges. Extracellular vesicles including exosomes have emerged as therape...

Ming Yue, Shengyun Hu, Haifeng Sun, Bao**g Tuo, Bin Jia, Chen Chen… in Molecular Cancer (2023)

Article

Effects of RNA methylation on Tumor angiogenesis and cancer progression

Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely observed in eukaryotes and prokaryotes. Accumulating studies h...

Mingyu Han, Haifeng Sun, Quanbo Zhou, **bo Liu, Junhong Hu… in Molecular Cancer (2023)

Article

Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity

Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has minimal benefit for patients in most types of cancer and is...

Senbo Liu, Wenkang Wang, Shengyun Hu, Bin Jia, Bao**g Tuo… in Cell Death & Disease (2023)

Article

Retraction Note: YAP1-induced MALAT1 promotes epithelial–mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer

Zhenqiang Sun, Chunlin Ou, **bo Liu, Chen Chen, Quanbo Zhou, Shuaixi Yang… in Oncogene (2023)

Article

Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

In recent years, tumor immunotherapy has made significant progress. However, tumor immunotherapy, particularly immune checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors), benefits only a tiny proportion of pat...

Hao Zhang, Lin Liu, **bo Liu, Pengyuan Dang, Shengyun Hu, Weitang Yuan… in Molecular Cancer (2023)

Article

Engineered exosomes from different sources for cancer-targeted therapy

Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and ...

Menghui Zhang, Shengyun Hu, Lin Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect

Cancer immunotherapy (CIT) has gained increasing attention and made promising progress in recent years, especially immune checkpoint inhibitors such as antibodies blocking programmed cell death 1/programmed ce...

Senbo Liu, Yan Zhang, Yang Liu, Wenkang Wang, Shuochen Gao… in British Journal of Cancer (2023)

Article

Exosomal circTUBGCP4 promotes vascular endothelial cell tip** and colorectal cancer metastasis by activating Akt signaling pathway

Exosome is crucial mediator and play an important role in tumor angiogenesis. Tip cell formation is a prerequisite for persistent tumor angiogenesis which causes tumor metastasis. However, the functions and un...

Chen Chen, Yang Liu, Lin Liu, Chaohua Si… in Journal of Experimental & Clinical Cancer … (2023)

Article

Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers

In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in only a small percentage of patient...

Li** Pei, Yang Liu, Lin Liu, Shuochen Gao, Xueyan Gao, Yudi Feng… in Molecular Cancer (2023)

Article

Roles of exosomal circRNAs in tumour immunity and cancer progression

Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of interc...

Bao**g Tuo, Zhuang Chen, Qin Dang, Chen Chen, Hao Zhang… in Cell Death & Disease (2022)

Article

Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer

Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology in colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs remains largely unexplored. In this s...

Zaoqu Liu, Long Liu, Siyuan Weng, Chunguang Guo, Qin Dang, Hui Xu… in Nature Communications (2022)

Article

Correction to: Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer

Dan Wang, Weitang Yuan, Ya** Wang, Qian Wu, Li Yang… in Journal of Translational Medicine (2021)

Article

Development and clinical validation of a novel six-gene signature for accurately predicting the recurrence risk of patients with stage II/III colorectal cancer

A large number of patients with stage II/III colorectal cancer (CRC) have a high recurrence rate after radical resection. We aimed to develop a novel tool to stratify patients with different recurrence-risk fo...

Zaoqu Liu, Taoyuan Lu, **g Li, Libo Wang, Kaihao Xu, Qin Dang… in Cancer Cell International (2021)

Article

Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis

Colorectal cancer (CRC) is one of the most common malignant tumours. The recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis is an extremely important cause of tumour ...

Yaxin Guo, Yuying Guo, Chen Chen, Dandan Fan, **aoke Wu, Luyang Zhao… in Molecular Cancer (2021)

Article

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by which TIME affects immunotherapy have not been eluci...

Zaoqu Liu, Yuyuan Zhang, Chengcheng Shi, Xueliang Zhou… in Journal of Translational Medicine (2021)

Article

MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis

Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elu...

Zhenqiang Sun, Qiuge Zhang, Weitang Yuan… in Journal of Experimental & Clinical Cancer … (2020)