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Article
Open AccessCharacterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that specifically occurs in pregnancy. Elevated levels of liver transaminases aspartate aminotransferase, alanine aminotransferase and serum bili...
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Article
Open AccessParkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma
The ubiquitin–proteasome system (UPS) is a tight homeostatic control mechanism of intracellular protein degradation and turnover involved in many human diseases. Proteasome inhibitors were initially developed ...
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Article
Open AccessAn oligonucleotide synthesizer based on a microreactor chip and an inkjet printer
Synthetic oligonucleotides (oligos) are important tools in the fields of molecular biology and genetic engineering. For applications requiring a large number of oligos with high concentration, it is critical t...
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Article
Open AccessTripole-mode and quadrupole-mode solitons in (1 + 1)-dimensional nonlinear media with a spatial exponential-decay nonlocality
The approximate analytical expressions of tripole-mode and quadrupole-mode solitons in (1 + 1)-dimensional nematic liquid crystals are obtained by applying the variational approach. It is found that the solito...
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Article
Open AccessPolarization domain wall pulses in a microfiber-based topological insulator fiber laser
Topological insulators (TIs), are novel two-dimension materials, which can act as effective saturable absorbers (SAs) in a fiber laser. Moreover, based on the evanescent wave interaction, deposition of the TI ...
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Article
Open AccessBioactivity of 2′-deoxyinosine-incorporated aptamer AS1411
Aptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2′-deoxyinosine in AS1411, an anti-proliferative G-rich oli...
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Article
Open AccessDifferential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservat...
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Article
Open AccessDiminished serum repetin levels in patients with schizophrenia and bipolar disorder
Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human brain, with relatively high leve...
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Article
Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors
The HIV-1 viral infectivity factor (VIF) protein is essential for viral replication. VIF recruits cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein APOBEC3G (A3G) for proteas...
