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Article
Open AccessCharacterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that specifically occurs in pregnancy. Elevated levels of liver transaminases aspartate aminotransferase, alanine aminotransferase and serum bili...
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Article
Propagation Characteristics of Higher-Order Mixed-Pattern Solitons in Nonlinear Media
In this paper, we study the propagation and evolution of higher-order mixed-pattern solitons in nonlinear media with a strong nonlocality. The propagation analytic formula of higher-order mixed-pattern soliton...
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Article
Open AccessParkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma
The ubiquitin–proteasome system (UPS) is a tight homeostatic control mechanism of intracellular protein degradation and turnover involved in many human diseases. Proteasome inhibitors were initially developed ...
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Article
Interface crack between dissimilar one-dimensional hexagonal quasicrystals with piezoelectric effect
In this paper, an interface crack between dissimilar one-dimensional (1D) hexagonal quasicrystals with piezoelectric effect under anti-plane shear and in-plane electric loadings is studied. By using integral t...
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Article
Open AccessAn oligonucleotide synthesizer based on a microreactor chip and an inkjet printer
Synthetic oligonucleotides (oligos) are important tools in the fields of molecular biology and genetic engineering. For applications requiring a large number of oligos with high concentration, it is critical t...
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Article
Required minimum cavity dispersion in stable, graphene mode-locked, Yb-doped fiber lasers
We have numerically investigated the required minimum cavity dispersion (RMCD) for obtaining stable pulses in net normal dispersion, graphene mode-locked, Yb-doped fiber lasers (YDFLs). By solving the modified...
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Article
Sine Hollow Solitons and Breathers in Nonlocal Media
The nonlocal nonlinear Schrödinger equation (NNLSE) describes the propagation dynamics of optical beams in nonlinear media with a spatial nonlocal response. Based on NNLSE, we obtain the generalized sine hollo...
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Article
Open AccessTripole-mode and quadrupole-mode solitons in (1 + 1)-dimensional nonlinear media with a spatial exponential-decay nonlocality
The approximate analytical expressions of tripole-mode and quadrupole-mode solitons in (1 + 1)-dimensional nematic liquid crystals are obtained by applying the variational approach. It is found that the solito...
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Article
Open AccessPolarization domain wall pulses in a microfiber-based topological insulator fiber laser
Topological insulators (TIs), are novel two-dimension materials, which can act as effective saturable absorbers (SAs) in a fiber laser. Moreover, based on the evanescent wave interaction, deposition of the TI ...
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Article
Open AccessBioactivity of 2′-deoxyinosine-incorporated aptamer AS1411
Aptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2′-deoxyinosine in AS1411, an anti-proliferative G-rich oli...
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Article
Open AccessDifferential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservat...
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Article
Analytic Expressions for the Interaction of Modified Hollow Gaussian Beams in Highly Nonlocal Nonlinear Media
We obtain two equivalent analytic expressions describing the propagation of two interacting modified hollow Gaussian beams in highly nonlocal nonlinear media. We carry out some numerical simulations to illustr...
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Article
Open AccessDiminished serum repetin levels in patients with schizophrenia and bipolar disorder
Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human brain, with relatively high leve...
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Article
Loss of silencing activity caused by 5′-terminal modification with d-/l-isonucleotide (isoNA) or locked nucleic acid (LNA) could not be restored by 5′-terminal phosphorylation
In this study, a series of 5′-phosphorylated siRNAs with d-/l-isonucleotide (isoNA) or locked nucleic acid (LNA) incorporated at the 5′-terminus were synthesized. It was found that after incorporating either isoN...
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Article
Synthesis and biological evaluation of peptide-siRNA conjugates with phosphodiester unit as linker
In this paper, a series of peptide-siRNA conjugates with phosphodiester unit as the linker targeting to Cdc2 gene were synthesized by solid phase stepwise strategy. The conjugation of peptides at either 3′-ter...
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Article
Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors
The HIV-1 viral infectivity factor (VIF) protein is essential for viral replication. VIF recruits cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein APOBEC3G (A3G) for proteas...
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Article
Discussion on the interrelationship among Cu-Ni sulfide deposits, mafic volcanic rocks and intrusive rocks in the Sipu region, northern Guangxi, China
The Sipu region of North Guangxi is located in the southwest of the “Jiangnan Ancient Land”, where there are developed the oldest stratum in southern China, the Proterozoic Sipu Group, and there are also large...
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Article
An adaptive scaled boundary finite element method by subdividing subdomains for elastodynamic problems
The scaled boundary finite element method (SBFEM) is a semi-analytical numerical method, which models an analysis domain by a small number of large-sized subdomains and discretises subdomain boundaries only. I...
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Article
Qualitative and Quantitative Determination of Oligonucleotides by Non-Gel Capillary Electrophoresis
A novel simple non-gel capillary electrophoresis (NGCE) method was developed for the qualitative and quantitative determination of oligonucleotides (ODNs). ODNs were synthesized in a DNA synthesizer and separa...
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Article
Finite Element Modelling of Complex 3D Static and Dynamic Crack Propagation by Embedding Cohesive Elements in Abaqus
This study proposes an algorithm of embedding cohesive elements in Abaqus and develops the computer code to model 3D complex crack propagation in quasi-brittle materials in a relatively easy and efficient mann...
