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  1. No Access

    Article

    Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives

    STING is an important immune-associated protein that localizes in the endoplasmic reticulum membrane. Upon being activated by its agonists, STING triggers the IRF and NF-κB pathways, which generates type I int...

    Rongyao Zhou, **yuan Wang, Deqiang Zhang, Zhengsheng Zhan… in Molecular Diversity (2023)

  2. No Access

    Article

    Synthesis of triazolotriazine derivatives as c-Met inhibitors

    Receptor tyrosine kinase c-Met is an important antitumor drug target. Triazolotriazine analogues 2–10 were prepared efficiently and evaluated the enzymatic and cellular c-Met activities. Brief structure–activity ...

    Yuting Guo, **a Peng, Yinchun Ji, Yitong Zhang, Jian Ding… in Molecular Diversity (2021)