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Article
Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives
STING is an important immune-associated protein that localizes in the endoplasmic reticulum membrane. Upon being activated by its agonists, STING triggers the IRF and NF-κB pathways, which generates type I int...
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Article
Open AccessStructural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation
Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonis...
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Article
Synthesis of triazolotriazine derivatives as c-Met inhibitors
Receptor tyrosine kinase c-Met is an important antitumor drug target. Triazolotriazine analogues 2–10 were prepared efficiently and evaluated the enzymatic and cellular c-Met activities. Brief structure–activity ...