10 Result(s)

Article

Intravenous infusion of small umbilical cord mesenchymal stem cells could enhance safety and delay retinal degeneration in RCS rats

Human umbilical cord mesenchymal stem cells (UCMSCs) transplantation is a promising therapy for the treatment of retinitis pigmentosa (RP). However, intravenously infused cells may be blocked in the lung, incr...

Qingling Liang, Qiyou Li, Bangqi Ren, Zheng Qin Yin in BMC Ophthalmology (2022)

Article

Organoid-derived C-Kit⁺/SSEA4⁻ human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, ...

Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen… in Nature Communications (2019)

Article

Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration

Stem cell therapy may provide a safe and promising treatment for retinal diseases. Wet age-related macular degeneration (wet-AMD) is a leading cause of blindness in China. We developed a clinical-grade human e...

Yong Liu, Hai Wei Xu, Lei Wang, Shi Ying Li, Cong Jian Zhao, Jie Hao… in Cell Discovery (2018)

Article

Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients

Retinitis pigmentosa is a common genetic disease that causes retinal degeneration and blindness for which there is currently no curable treatment available. Vision preservation was observed in retinitis pigmen...

Yong Liu, Shao Jun Chen, Shi Ying Li, Ling Hui Qu… in Stem Cell Research & Therapy (2017)

Article

Improved retinal function in RCS rats after suppressing the over-activation of mGluR5

Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptor...

Jiaman Dai, Yan Fu, Yuxiao Zeng, Shiying Li, Zheng Qin Yin in Scientific Reports (2017)

Article

Functional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats

Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and func...

Yan Fu, Baoke Hou, Chuanhuang Weng, Wei** Liu, Jiaman Dai… in Scientific Reports (2017)

Article

Combined transplantation of human mesenchymal stem cells and human retinal progenitor cells into the subretinal space of RCS rats

Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cell...

Linghui Qu, Lixiong Gao, Haiwei Xu, ** Duan, Yuxiao Zeng, Yong Liu… in Scientific Reports (2017)

Article

Grafted c-kit⁺/SSEA1⁻ eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses

Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacem...

** Chen, Zehua Chen, Zhengya Li, Chen Zhao, Yuxiao Zeng… in Stem Cell Research & Therapy (2016)

Article

Intermittent high oxygen influences the formation of neural retinal tissue from human embryonic stem cells

The vertebrate retina is a highly multilayered nervous tissue with a large diversity of cellular components. With the development of stem cell technologies, human retinas can be generated in three-dimensional ...

Lixiong Gao, ** Chen, Yuxiao Zeng, Qiyou Li, Ting Zou, Siyu Chen… in Scientific Reports (2016)

Article

Erratum to: A novel mutation in C5L2 gene was associated with hyperlipidemia and retinitis pigmentosa in a Chinese family

Ling-hui Qu, **n **, Liang-mao Li, Shi-ying Li… in Lipids in Health and Disease (2014)