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Article
Open AccessOrganoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, ...
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Article
Open AccessImproved retinal function in RCS rats after suppressing the over-activation of mGluR5
Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptor...
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Article
Open AccessFunctional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats
Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and func...
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Article
Open AccessCombined transplantation of human mesenchymal stem cells and human retinal progenitor cells into the subretinal space of RCS rats
Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cell...
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Article
Open AccessIntermittent high oxygen influences the formation of neural retinal tissue from human embryonic stem cells
The vertebrate retina is a highly multilayered nervous tissue with a large diversity of cellular components. With the development of stem cell technologies, human retinas can be generated in three-dimensional ...
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Prevalence and Risk Factors for Age-Related Macular Degeneration in China