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  1. Article

    Open Access

    Organoid-derived C-Kit+/SSEA4 human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

    Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, ...

    Ting Zou, Lixiong Gao, Yuxiao Zeng, Qiyou Li, Yijian Li, Siyu Chen in Nature Communications (2019)

  2. Article

    Open Access

    Improved retinal function in RCS rats after suppressing the over-activation of mGluR5

    Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptor...

    Jiaman Dai, Yan Fu, Yuxiao Zeng, Shiying Li, Zheng Qin Yin in Scientific Reports (2017)

  3. Article

    Open Access

    Functional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats

    Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and func...

    Yan Fu, Baoke Hou, Chuanhuang Weng, Wei** Liu, Jiaman Dai in Scientific Reports (2017)

  4. Article

    Open Access

    Combined transplantation of human mesenchymal stem cells and human retinal progenitor cells into the subretinal space of RCS rats

    Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cell...

    Linghui Qu, Lixiong Gao, Haiwei Xu, ** Duan, Yuxiao Zeng, Yong Liu in Scientific Reports (2017)

  5. Article

    Open Access

    Intermittent high oxygen influences the formation of neural retinal tissue from human embryonic stem cells

    The vertebrate retina is a highly multilayered nervous tissue with a large diversity of cellular components. With the development of stem cell technologies, human retinas can be generated in three-dimensional ...

    Lixiong Gao, ** Chen, Yuxiao Zeng, Qiyou Li, Ting Zou, Siyu Chen in Scientific Reports (2016)

  6. No Access

    Chapter

    Prevalence and Risk Factors for Age-Related Macular Degeneration in China

    Zheng Qin Yin, Meidong Zhu, Wen Shan Jiang in Macular Degeneration (2005)