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Article
Open AccessIntravenous infusion of small umbilical cord mesenchymal stem cells could enhance safety and delay retinal degeneration in RCS rats
Human umbilical cord mesenchymal stem cells (UCMSCs) transplantation is a promising therapy for the treatment of retinitis pigmentosa (RP). However, intravenously infused cells may be blocked in the lung, incr...
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Article
Open AccessOrganoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents
Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, ...
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Article
Open AccessHuman embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration
Stem cell therapy may provide a safe and promising treatment for retinal diseases. Wet age-related macular degeneration (wet-AMD) is a leading cause of blindness in China. We developed a clinical-grade human e...
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Article
Open AccessLong-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients
Retinitis pigmentosa is a common genetic disease that causes retinal degeneration and blindness for which there is currently no curable treatment available. Vision preservation was observed in retinitis pigmen...
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Article
Open AccessImproved retinal function in RCS rats after suppressing the over-activation of mGluR5
Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptor...
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Article
Open AccessFunctional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats
Following retinal degeneration, retinal remodeling can cause neuronal microcircuits to undergo structural alterations, which particularly affect the dendrites of bipolar cells. However, the mechanisms and func...
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Article
Open AccessCombined transplantation of human mesenchymal stem cells and human retinal progenitor cells into the subretinal space of RCS rats
Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cell...
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Usher Syndrome in Chinese and Japanese Population
Usher syndrome (USH) is the most common cause of combined blindness and deafness inherited in an autosomal recessive mode. It is clinically and genetically heterogeneous and is the most common cause underlying...
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Article
Open AccessGrafted c-kit+/SSEA1− eye-wall progenitor cells delay retinal degeneration in mice by regulating neural plasticity and forming new graft-to-host synapses
Despite diverse pathogenesis, the common pathological change observed in age-related macular degeneration and in most hereditary retinal degeneration (RD) diseases is photoreceptor loss. Photoreceptor replacem...
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Article
Open AccessIntermittent high oxygen influences the formation of neural retinal tissue from human embryonic stem cells
The vertebrate retina is a highly multilayered nervous tissue with a large diversity of cellular components. With the development of stem cell technologies, human retinas can be generated in three-dimensional ...
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Article
Detecting novel genetic mutations in Chinese Usher syndrome families using next-generation sequencing technology
Usher syndrome (USH) is the most common cause of combined blindness and deafness inherited in an autosomal recessive mode. Molecular diagnosis is of great significance in revealing the molecular pathogenesis a...
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Article
Open AccessErratum to: A novel mutation in C5L2 gene was associated with hyperlipidemia and retinitis pigmentosa in a Chinese family
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Article
Effect of Optogenetic Stimulus on the Proliferation and Cell Cycle Progression of Neural Stem Cells
Modulation of stem cell proliferation is a crucial aspect of neural developmental biology and regenerative medicine. To investigate the effect of optical stimulation on neural stem cell proliferation, cells tr...
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Article
Alterations of Sodium and Potassium Channels of RGCs in RCS Rat with the Development of Retinal Degeneration
All know that retinitis pigmentosa (RP) is a group of hereditary retinal degenerative diseases characterized by progressive dysfunction of photoreceptors and associated with progressive cells loss; nevertheles...
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Article
Slow Regulated Release of H2S Inhibits Oxidative Stress Induced Cell Death by Influencing Certain Key Signaling Molecules
Hydrogen sulphide (H2S) is one of three gaseous signaling molecules after nitric oxide and carbon monoxide. Various H2S donor compounds have been synthesized to study its physiological function. Among these compo...
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Article
The Influence of NaIO3-Induced Retinal Degeneration on Intra-retinal Layer and the Changes of Expression Profile/Morphology of DA-ACs and mRGCS
Sodium iodate (NaIO3)-induced retina injury is one of models that is commonly used to study various retinal diseases caused by retinal pigment epithelium (RPE) injury such as AMD. Previous researches have reveale...
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Article
The characterization of functional disturbances in Chinese patients with Bietti’s crystalline dystrophy at different fundus stages
The aim of this study was to characterize the functional and clinical disturbances and screen the optimal functional tests in assessing Bietti’s crystalline dystrophy (BCD) patients by a cross-sectional method.
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Article
Alpha-Crystallin Promotes Rat Axonal Regeneration Through Regulation of RhoA/Rock/Cofilin/MLC Signaling Pathways
Intravitreal injection of α-crystallin can promote axons from optic nerve regeneration after crushing in rats. We have previously demonstrated that α-crystallin can counteract the effect of myelin inhibitory f...
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Article
Somatic and stem cell pairing and fusion using a microfluidic array device
There is considerable excitement about the prospect of tissue repair and renewal through cell replacement therapies. Nonetheless, many of these techniques may require the reprogramming of somatic and stem cell...
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Article
Temporal and spatial characteristics of cone degeneration in RCS rats
The temporal and spatial characteristics of cone degeneration in the Royal College of Surgeons (RCS) rat were studied to provide information for treatment strategies of retinitis pigmentosa.
