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  1. Article

    Open Access

    Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study

    This study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma (HCC) associated with metabolic dysfunction-related fatty liver dis...

    Da-Long Yang, Shao-** Liu, Hong-Liang Wang, Jian-Rong Li… in Infectious Agents and Cancer (2024)

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  2. No Access

    Article

    JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit

    Histone modification plays an important role in pathological cardiac hypertrophy and heart failure. In this study we investigated the role of a histone arginine demethylase, Jumonji C domain-containing protein...

    Zhen Guo, Yue-huai Hu, Guo-shuai Feng… in Acta Pharmacologica Sinica (2023)

  3. No Access

    Article

    GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level

    Numerous studies reveal that metabolism dysfunction contributes to the development of pathological cardiac hypertrophy. While the abnormal lipid and glucose utilization in cardiomyocytes responding to hypertro...

    Zhi-Rong Lin, Zhen-Zhen Li, Yan-Jun Cao… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2022)

  4. No Access

    Article

    Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission

    Tweety-homolog 1 (Ttyh1) is expressed in neural tissue and has been implicated in the generation of several brain diseases. However, its functional significance in pain processing is not understood. By disrupt...

    Wen-Juan Han, Sui-Bin Ma, Wen-Bin Wu, Fu-Dong Wang, **u-Li Cao… in Neuroscience Bulletin (2021)

  5. Article

    Open Access

    Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons

    Previous studies have shown that CCL2 (C–C motif chemokine ligand 2) induces chronic pain, but the exact mechanisms are still unknown. Here, we established models to explore the potential mechanisms. Behaviora...

    Hui Zhang, Sui-Bin Ma, Yong-**g Gao, Jun-Ling **ng, Hang **an… in Neuroscience Bulletin (2020)

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  6. No Access

    Article

    Firing Pattern Modulation Through SK Channel Current Increase Underlies Neuronal Survival in an Organotypic Slice Model of Parkinson’s Disease

    Dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) are vulnerable to excitotoxicity in Parkinson’s disease (PD). Neurotoxic stimuli may alter the firing patterns of DA neurons. However, whether ...

    Yuan Wang, Liang Qu, Xue-Lian Wang, Li Gao, Zhen-Zhen Li… in Molecular Neurobiology (2015)