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Open AccessProbabilistic sunspot predictions with a gated recurrent units-based combined model guided by pinball loss
Sunspots play a crucial role in both weather forecasting and the monitoring of solar storms. In this work, we propose a novel combined model for sunspot prediction using improved gated recurrent units (GRU) gu...
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Article
Open AccessTargeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis
Primary biliary cholangitis (PBC) is a cholestatic autoimmune liver disease characterized by autoreactive T cell response against intrahepatic small bile ducts. Here, we use Il12b-/-Il2ra-/- mice (DKO mice) as a ...
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Open AccessSystematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric...
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Open AccessEfficacy and safety profile of angiotensin receptor neprilysin inhibitors in the management of heart failure: a systematic review and meta-analysis of randomized controlled trials
Several guidelines have recommended the use of angiotensin receptor neprilysin inhibitors (ARNIs) as replacement for angiotensin-converting enzyme inhibitors in the management of heart failure. Till date, ther...
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Open AccessCorrection: Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica
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Open AccessComprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica
Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined.
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Article
Open AccessNotch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer
The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Not...
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Open AccessGradually shifting clinical phenomics in migraine spectrum: a cross-sectional, multicenter study of 5438 patients
The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum.
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Open AccessGene co-expression network based on part mutual information for gene-to-gene relationship and gene-cancer correlation analysis
Finding correlation patterns is an important goal of analyzing biological data. Currently available methods for correlation analysis mainly use non-direct associations, such as the Pearson correlation coeffici...
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Article
Open AccessChromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity
Activation of adipose tissue macrophages (ATMs) contributes to chronic inflammation and insulin resistance in obesity. However, the transcriptional regulatory machinery involved in ATM activation during the de...
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Article
Effect of mould baffle technology on stray grain formation in single crystal blades by integral fabrication based on 3D printing
Stray grains, the most serious casting defect, mainly occur in the platform because of the abrupt transition of the cross-section in the directional solidification of superalloy single-crystal blades. A new mo...
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Open AccessMulti-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming
Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (Fo...
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Open AccessPotent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure
Optimal cell type as cell-based therapies for heart failure (HF) remains unclear. We sought to compare the safety and efficacy of direct intramyocardial transplantation of human embryonic stem cell-derived car...
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Open AccessA Mouse Model of Autoimmune Cholangitis via Syngeneic Bile Duct Protein Immunization
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and ev...
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Open AccessCut-off optimization for 13C-urea breath test in a community-based trial by mathematic, histology and serology approach
The performance of diagnostic tests in intervention trials of Helicobacter pylori (H.pylori) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for 13C-ure...
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Open AccessModulation of liver regeneration via myeloid PTEN deficiency
Molecular mechanisms that modulate liver regeneration are of critical importance for a number of hepatic disorders. Kupffer cells and natural killer (NK) cells are two cell subsets indispensable for liver rege...
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Open AccessBlock of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development
Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β ...
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Open AccessRetraction Note: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection
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Open AccessRETRACTED ARTICLE: Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection
To comparatively evaluate the cardioprotective activity of placental growth factor (PGF) delivered through direct injection and a nanoparticle-based system respectively and to study the underlying mechanisms i...