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Article
Open AccessHighly efficient octave-spanning long-wavelength infrared generation with a 74% quantum efficiency in a χ(2) waveguide
The realization of compact and efficient broadband mid-infrared (MIR) lasers has enormous impacts in promoting MIR spectroscopy for various important applications. A number of well-designed waveguide platforms...
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Article
Diagnostic and prognostic performance of plasma neurofilament light chain in multiple system atrophy: a cross-sectional and longitudinal study
The longitudinal dynamics of neurofilament light chain (NfL) in multiple system atrophy (MSA) were incompletely illuminated. This study aimed to explore whether the plasma NfL (pNfL) could serve as a potential...
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Article
Open AccessHigh-harmonic generation in CdTe with ultra-low pump intensity and high photon flux
An ultra-low pump intensity and high photon flux have been long pursuits of high harmonic generation (HHG) in solids. However, there is lack of a criterion to identify a pristine solid material exhibiting such...
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Article
Associated factors and abnormal dorsal raphe nucleus connectivity patterns of freezing of gait in Parkinson’s disease
Freezing of gait (FOG) is a common, disabling symptom of Parkinson’s disease (PD), and its exact pathophysiological mechanism is still poorly understood. The control of gait is a complex process that may be in...
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Article
Coffin-Siris syndrome in two chinese patients with novel pathogenic variants of ARID1A and SMARCA4
Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by developmental delay, intellectual disability, microcephaly, coarse face and hypoplastic nail of the fifth digits. Heterozygous variant...
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Article
Identification of the Largest SCA36 Pedigree in Asia: with Multimodel Neuroimaging Evaluation for the First Time
Spinocerebellar ataxias (SCAs) are a large group of hereditary neurodegenerative diseases characterized by ataxia and dysarthria. Due to high clinical and genetic heterogeneity, many SCA families are undiagnos...
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Article
Open AccessThe progression rate of spinocerebellar ataxia type 3 varies with disease stage
In polyglutamine (polyQ) diseases, the identification of modifiers and the construction of prediction model for progression facilitate genetic counseling, clinical management and therapeutic interventions.
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Article
Heterogeneity of behavioural and language deficits in FTD–MND
To comprehensively examine the clinical presentation of patients diagnosed with frontotemporal dementia–motor neuron disease (FTD–MND) compared to FTD subtypes. To clarify the heterogeneity of behavioural and ...
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Chapter and Conference Paper
Optimization and Deployment of Vehicle Trajectory Prediction Scheme Based on Real-Time ANPR Traffic Big Data
Path prediction is an important issue in traffic management. In big data environment, the real-time ANPR (Automatic Number Plate Recognition) data can provide evident support for path prediction. Taking advan...
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Article
A Novel Integrated Approach for Companion Vehicle Discovery Based on Frequent Itemset Mining on Spark
Companion vehicle discovery received much attention from the research community. It has been widely adopted by traffic management departments in many aspects such as the involved vehicle tracking. Since there ...
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Article
Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia–motor neuron disease patients
This study systematically investigated the neuropsychological profile of language disturbance in frontotemporal dementia–motor neuron disease (FTD–MND) using a data-driven approach. Neuroanatomical correlates ...
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Article
Reliability Evaluation of Machine Center Components Based on Cascading Failure Analysis
In order to rectify the problems that the component reliability model exhibits deviation, and the evaluation result is low due to the overlook of failure propagation in traditional reliability evaluation of ma...
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Article
Open AccessIdentification of a de novo DYNC1H1 mutation via WES according to published guidelines
De novo mutations that contribute to rare Mendelian diseases, including neurological disorders, have been recently identified. Whole-exome sequencing (WES) has become a powerful tool for the identification of inh...
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Article
Open AccessAlleviating neurodegeneration in Drosophila models of PolyQ diseases
Polyglutamine (polyQ) diseases are a group of neurodegenerative conditions, induced from CAG trinucleotide repeat expansion within causative gene respectively. Generation of toxic proteins, containing polyQ-ex...
