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Article
Open AccessIdentification and pathogenicity of Fusarium spp. associated with tea wilt in Zhejiang Province, China
Tea is one of the most widely consumed beverages in the world, with significant economic and cultural value. However, tea production faces many challenges due to various biotic and abiotic stresses, among whic...
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Article
CD318 is a target of chimeric antigen receptor T cells for the treatment of colorectal cancer
Colorectal cancer (CRC) currently has a poor prognosis with a 6.9-year median survival time; to relieve this malignant cancer, we proposed to establish CRC xenografts that can be used to evaluate the cytotoxic...
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Article
Open AccessIntegrated next-generation sequencing and comparative transcriptomic analysis of leaves provides novel insights into the ethylene pathway of Chrysanthemum morifolium in response to a Chinese isolate of chrysanthemum virus B
Chrysanthemum virus B (CVB), a key member of the genus Carlavirus, family Betaflexiviridae, causes severe viral diseases in chrysanthemum (Chrysanthemum morifolium) plants worldwide. However, information on the m...
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Article
Open AccessCo-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis
Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the antitumor effects of chimeric antigen receptor (CAR) T cells. However, the effects of trans-recognition between CSRs and PD-L1 ...
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Article
Comparative study of treatment for striae alba stage striae gravidarum: 1565-nm non-ablative fractional laser versus fractional microneedle radiofrequency
Striae gravidarum is a common dermatologic condition for females caused by multiple factors during pregnancy. It remains a therapeutic challenge especially in the striae alba (SA) stage, generating psychologic...
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Article
Open AccessIL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin
Although chimeric antigen receptor (CAR)-engineered T cells have shown great success in the treatment of B cell malignancies, this strategy has limited efficacy in patients with solid tumors. In mouse CAR-T ce...
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Article
IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells
Chimeric antigen receptor (CAR) T cell therapies lead to high clinical response rates in B cell malignancies, and are under investigation for treatment of solid tumors. While high systemic interleukin- (IL-) 6...
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Article
Open AccessThe association of metabolic syndrome and cognitive impairment in Jidong of China: a cross-sectional study
Metabolic syndrome (Mets) is prevalent in the general population and has been reported to be an independent risk factor for cognitive impairment. This study aimed to investigate the association of Mets with th...
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Article
The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection
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Article
Open AccessHigh sensitivity of one-step real-time reverse transcription quantitative PCR to detect low virus titers in large mosquito pools
Mosquitoes are the deadliest animals in the world. Their ability to carry and spread diseases to humans causes millions of deaths every year. Due to the lack of efficient vaccines, the control of mosquito-born...
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Article
Open AccessCorrection to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia
The original article [1] contains an error in authorship whereby author, Robert Weinkove’s name is mistakenly inverted. The configuration noted in this Correction article should be considered instead along wit...
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Article
Open AccessMesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen recept...
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Article
Open AccessArsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14–3-3η/NF-κB feedback loop
Multi-drug resistance (MDR) is one of the main obstacles for treatment of advanced/recurrent hepatocellular carcinoma (HCC). We have previously identified arsenic trioxide (ATO) as an effective metastasis/angi...
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Article
Open AccessA novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia
Anti-CD19 chimeric antigen receptor (CAR) T cells have shown promise in the treatment of B cell acute lymphocytic leukemia (B-ALL). However, its efficacy in B-ALL patients with extramedullary involvement is li...
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Article
MiR-491 attenuates cancer stem cells-like properties of hepatocellular carcinoma by inhibition of GIT-1/NF-κB-mediated EMT
Hepatocellular carcinoma (HCC) is the most common liver malignancy. Current standard practices for treatment of HCC are less than satisfactory because of CSCs-mediated recurrence. For this reason, targeting CS...
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Article
Open AccessEstimates for the composition of the carathéodory and homotopy operators
In the present paper, we deal with the composition of carathéodory and homotopy operators for differential forms satisfying the A-harmonic equation in the bounded and convex domain. We obtain estimates for the co...
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Article
Open AccessCaratheodory operator of differential forms
This article is devoted to extensions of some existing results about the Caratheodory operator from the function sense to the differential form situation. Similarly as the function sense, we obtain the converg...
