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Article
Open AccessSpecific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats
Cognitive impairment frequently presents as a prevalent consequence following stroke, imposing significant burdens on patients, families, and society. The objective of this study was to assess the effectivenes...
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Article
Open AccessAuthor Correction: Design of robotic arm for the porcelain bushing in substation
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Article
Open AccessThe UF-5000 Atyp.C parameter is an independent risk factor for bladder cancer
Bladder carcinoma (BC) accounts for > 90% of all urothelial cancers. Pathological diagnosis through cytoscopic biopsy is the gold standard, whereas non-invasive diagnostic tools remain lacking. The “Atyp.C” pa...
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Article
Open AccessExtrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
Extrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a...
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Article
Open AccessResearch on fault identification of high-voltage circuit breakers with characteristics of voiceprint information
High voltage circuit breakers are one of the core equipment in power system operation, and the voiceprint signals generated during operation contain extremely rich information. This paper proposes a fault iden...
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Article
Open AccessDesign of robotic arm for the porcelain bushing in substation
With the development and the application popularization of artificial intelligence robot technology and 5G technology, a robotic arm is designed and developed for rinsing porcelain bushing in high voltage subs...
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Article
Open AccessFailure mode and effects analysis using an improved pignistic probability transformation function and grey relational projection method
Failure mode and effects analysis (FMEA) is an important risk analysis tool that has been widely used in diverse areas to manage risk factors. However, how to manage the uncertainty in FMEA assessments is stil...
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Article
Open AccessFriction injury of the central vein caused by catheter for hemodialysis: an in vitro study
Vascular injury such as central venous stenosis (CVS) is a common complication in hemodialysis patients with central venous catheters (CVCs), yet the impact of the microstructure and partial physic characteris...
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Article
Open AccessSTK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of critical cell growth regulators that lead to uncontrolled proliferation and increased mal...
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Article
Open AccessAnalysis of heterologous expression of phaCBA promotes the acetoin stress response mechanism in Bacillus subtilis using transcriptomics and metabolomics approaches
Acetoin, a versatile platform chemical and popular food additive, poses a challenge to the biosafety strain Bacillus subtilis when produced in high concentrations due to its intrinsic toxicity. Incorporating the ...
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Article
Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...
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Article
Open AccessSim-GAIL: A generative adversarial imitation learning approach of student modelling for intelligent tutoring systems
The continuous application of artificial intelligence (AI) technologies in online education has led to significant progress, especially in the field of Intelligent Tutoring Systems (ITS), online courses and le...
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Article
Open AccessIdentification of a c-type heme oxygenase and its function during acclimation of cyanobacteria to nitrogen fluctuations
The mechanisms of acclimating to a nitrogen-fluctuating environment are necessary for the survival of aquatic cyanobacteria in their natural habitats, but our understanding is still far from complete. Here, th...
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Article
Open AccessTargeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia
Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate of drug resistance limits its clinical applica...
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Article
Open AccessIL-27 induces autophagy through regulation of the DNMT1/lncRNA MEG3/ERK/p38 axis to reduce pulmonary fibrosis
Previous studies have shown that interleukin-27 (IL-27) can reduce bleomycin (BLM)-induced pulmonary fibrosis (PF). However, the underlying mechanism by which IL-27 attenuates PF is not fully clear.
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Article
Open AccessProduction of acetoin and its derivative tetramethylpyrazine from okara hydrolysate with Bacillus subtilis
Okara, a renewable biomass resource, is a promising fermentative raw material for the bio-production of value-added chemicals due to its abundance and low-costs. we developed a process for the enzymatic hydrol...
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Chapter and Conference Paper
Research on Theoretical Framework and Implementation Path of Green Maintenance of Inland Waterway
Inland waterway maintenance could guarantee channel dimension and maintain navigation conditions. With the continuous increase of channel mileage, inland waterway maintenance gradually became more frequent and...
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Article
Open AccessAssessment of biosafety and implantation feasibility of novel phakic refractive lens
We investigated the biosafety and implantation feasibility of a new phakic refractive lens (PRL) in rabbit eyes.
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Article
Open AccessComparison of weight loss induced by daily caloric restriction versus intermittent fasting (DRIFT) in individuals with obesity: study protocol for a 52-week randomized clinical trial
The standard of care for treating overweight and obesity is daily caloric restriction (DCR). While this approach produces modest weight loss, adherence to DCR declines over time and weight regain is common. In...
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Article
Open AccessTargeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer
Prostate cancer (PCa) is one of the most prevalent cancers in men worldwide, and hormonal therapy plays a key role in the treatment of PCa. However, the drug resistance of hormonal therapy makes it urgent and ...
