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  1. No Access

    Article

    CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

    Recurrent oncogenic mutations of MyD88 have been identified in a variety of lymphoid malignancies. Gain-of-function mutations of MyD88 constitutively activate downstream NF-κB signaling pathways, resulting in ...

    **aofeng **, Qing Shi, Qian Li, Linyi Zhou, Jian Wang, Lei Jiang, **aying Zhao… in Leukemia (2020)

  2. Article

    Open Access

    lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

    MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signalin...

    **chang Pan, Shuai Fang, Haihua Tian, Chengwei Zhou, **aodong Zhao… in Molecular Cancer (2020)

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  3. Article

    Open Access

    Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

    Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified.

    Qirong Geng, Jianjun Liu, Zhaohui Gong, Shangxiang Chen, Shuai Chen… in Molecular Cancer (2017)

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  4. No Access

    Chapter

    The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy

    Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue d...

    Zhaohui Gong, Zhuo Dong, Lihua Yang, Jie Yang… in MicroRNA Targeted Cancer Therapy (2014)

  5. No Access

    Article

    MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells

    MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung cancer development. However, the interact...

    Zhiwei Zhong, Zhuo Dong, Lihua Yang, **aoqiang Chen, Zhaohui Gong in Tumor Biology (2013)

  6. No Access

    Article

    miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer

    MicroRNAs regulate critical genes associated with lung cancer. Human mutS homolog 2 (hMSH2), one of the core mismatch repair genes, is affected in lung cancer development. The aim of this study is to investigate ...

    Zhiwei Zhong, Zhuo Dong, Lihua Yang… in Journal of Cancer Research and Clinical On… (2012)

  7. No Access

    Article

    Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells

    The let-7 family of microRNAs (miRNAs) are known to act as tumor suppressors and down-regulated in lung cancer. Recently, the RNA-binding protein Lin-28 was demonstrated to inhibit biogenesis of let-7 miRNAs b...

    Lin Pan, Zhaohui Gong, Zhiwei Zhong, Zhuo Dong… in Molecular and Cellular Biochemistry (2011)