![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessPhenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing
Trio-based whole-exome sequencing (trio-WES) enables identification of pathogenic variants, including copy-number variants (CNVs), in children with unexplained neurodevelopmental delay (NDD) and neurodevelopme...
-
Article
Open AccessDemystifying COVID-19 mortality causes with interpretable data mining
While COVID-19 becomes periodical, old individuals remain vulnerable to severe disease with high mortality. Although there have been some studies on revealing different risk factors affecting the death of COVI...
-
Article
Open AccessAssessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake
To validate the feasibility of water enema PET/CT (WE-PET/CT) in incidental colorectal 18F-FDG uptake and improve the accuracy of diagnosing colorectal neoplastic lesions.
-
Article
Open AccessMCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer
Microchromosome maintenance (MCM) proteins are a number of nuclear proteins with significant roles in the development of cancer by influencing the process of cellular DNA replication. Of the MCM protein family...
-
Article
Open AccessRetrosynthetic planning with experience-guided Monte Carlo tree search
In retrosynthetic planning, the huge number of possible routes to synthesize a complex molecule using simple building blocks leads to a combinatorial explosion of possibilities. Even experienced chemists often...
-
Article
Capacity pooling games in crowdsourcing services
In crowdsourcing services, employers often post some complex (or difficult) tasks that individual workers cannot complete independently. In this paper, we investigate that a group of independent workers willin...
-
Article
Open AccessSARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...
-
Article
Open AccessClinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis
Nonerythrocytic spectrin beta 1 (SPTBN1) is an important cytoskeletal protein that involves in normal cell growth and development via regulating TGFβ/Smad signaling pathway, and is aberrantly expressed in vari...
-
Article
Open AccessStudy on grid inefficiency for mesh-type Frisch-grid ionization chambers
In this study, the grid inefficiency \(\sigma \) σ for a mesh-type Frisch-g...
-
Article
Open AccessIdentification and validation of a novel 16-gene prognostic signature for patients with breast cancer
Despite increased early diagnosis and improved treatment in breast cancer (BRCA) patients, prognosis prediction is still a challenging task due to the disease heterogeneity. This study was to identify a novel ...
-
Article
Retraction Note: Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta‑analysis
-
Article
Open AccessMiR-106b-5p regulates esophageal squamous cell carcinoma progression by binding to HPGD
Several studies have documented the key role of microRNAs (miRNAs) in esophageal squamous cell carcinoma (ESCC). Although the expression of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and miR-106b-5p ar...
-
Article
RETRACTED ARTICLE: Osteotomy in lateral position for correcting severe thoracolumbar kyphosis combined with hip flexion contracture in ankylosing spondylitis: a case report and literature review
-
Article
Open AccessEffect of cyclic wetting–drying on tensile mechanical behavior and microstructure of clay-bearing sandstone
The understanding of the weakening mechanism of tensile strength of rock subjected to cyclic wetting-drying is critical for rock engineering. Tensile strength tests were conducted on a total of 35 sandstone sp...
-
Article
Open AccessFish bone-derived interconnected carbon nanofibers for efficient and lightweight microwave absorption
In this work, we demonstrated a simple method for preparing three-dimensional interconnected carbon nanofibers (ICNF) derived from fish bone as an efficient and lightweight microwave absorber. The as-obtained ...
-
Article
LAMOST’s view on the Gaia-Sausage-Enceladus merger event
-
Article
Open AccessVariation of rhizosphere microbial community in continuous mono-maize seed production
Soil microbe is crucial to a healthy soil, therefore its diversities and abundances under different conditions are still need fully understand.The aims of the study were to characterize the community structure...
-
Article
Open AccessHeterotrimeric G-protein α subunit (LeGPA1) confers cold stress tolerance to processing tomato plants (Lycopersicon esculentum Mill)
Tomatoes (Lycopersicon esculentum Mill) are key foods, and their molecular biology and evolution have been well described. Tomato plants originated in the tropics and, thus, are cold sensitive.
-
Article
Open AccessDiagnostic performance of ultrasonography, dual-phase 99mTc-MIBI scintigraphy, early and delayed 99mTc-MIBI SPECT/CT in preoperative parathyroid gland localization in secondary hyperparathyroidism
Secondary hyperparathyroidism (SHPT) usually requires parathyroidectomy when drug regimens fail. However, obtaining an exact preoperative map of the locations of the parathyroid glands is a challenge. The purp...
-
Article
Open AccessEravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus
Our previous research indicated the excellent in vitro antibacterial activity of Eravacycline (Erava) and its heteroresistance frequency against clinical Staphylococcus aureus isolates. In this study, we further ...